Publication Name	World Journal of Clinical Cases
Manuscript ID	47402
Country	Türkiye

Received	2019-03-20 01:47
Peer-Review Started	2019-03-22 09:32
To Make the First Decision	2019-04-18 03:46
Return for Revision	2019-04-19 09:57
Revised	2019-05-18 09:32
Second Decision	2019-06-10 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-06-10 22:08
Articles in Press	2019-06-10 22:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-07-23 00:38
Publish the Manuscript Online	2019-07-26 10:13

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Minireviews
Article Title	New treatment modalities in Alzheimer's disease
Manuscript Source	Invited Manuscript
All Author List	Emel Koseoglu
ORCID	Author(s) ORCID Number Emel Koseoglu http://orcid.org/0000-0001-9620-9949
Funding Agency and Grant Number
Corresponding Author	Emel Koseoglu, MD, Professor, Department of Neurology, Faculty of Medicine, Erciyes University, Kayseri 38039, Türkiye. emelk@erciyes.edu.tr
Key Words	Alzheimer’s disease treatment; Anti-amyloid, anti-tau; Gamma oscillations; Stem cell therapy; ;
Core Tip	This review discusses various new treatment modalities in Alzheimer’s disease (AD) based on the classification of their mechanism of action. New anti-amyloid, anti-tau, and treatments targeting network dysfunction with particular attention to deep brain stimulation to modulate gamma oscillations in the brain are evaluated. Moreover exciting developments in stem cell therapy especially combined with tissue engineering techniques are presented. Lastly some other modalities including microglial function modulators, gut microbiome transplantation, modulation of vagus nerve and metabolic arrangements are mentioned. It seems that new treatments in AD will involve each of them individually or in combination.
Publish Date	2019-07-26 10:13
Citation	Koseoglu E. New treatment modalities in Alzheimer's disease. World J Clin Cases 2019; 7(14): 1764-1774
URL	https://www.wjgnet.com/2307-8960/full/v7/i14/1764.htm
DOI	https://dx.doi.org/10.12998/wjcc.v7.i14.1764

Full Article (PDF)	WJCC-7-1764.pdf
Full Article (Word)	WJCC-7-1764.docx
Manuscript File	47402-Review.docx
Answering Reviewers	47402-Answering reviewers.pdf
Audio Core Tip	47402-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	47402-Conflict-of-interest statement.pdf
Copyright License Agreement	47402-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	47402-Language certificate.pdf
Peer-review Report	47402-Peer-review(s).pdf
Scientific Misconduct Check	47402-Scientific misconduct check.pdf
Scientific Editor Work List	47402-Scientific editor work list.pdf
CrossCheck Report	47402-CrossCheck report.pdf