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Articles Published Processes
12/31/2019 7:02:25 AM | Browse: 840 | Download: 1498
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Received |
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2019-03-22 02:28 |
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Peer-Review Started |
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2019-03-22 08:32 |
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To Make the First Decision |
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2019-08-01 00:13 |
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Return for Revision |
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2019-08-26 09:16 |
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Revised |
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2019-10-10 06:13 |
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Second Decision |
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2019-10-14 08:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-10-14 17:01 |
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Articles in Press |
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2019-10-14 17:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-12-02 01:50 |
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Publish the Manuscript Online |
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2019-12-31 07:02 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Evidence-Based Medicine |
| Article Title |
Validity of studies suggesting preoperative chemotherapy for resectable thoracic esophageal cancer: A critical appraisal of randomized trials
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Giulia Manzini, Ursula Klotz, Doris Henne-Bruns and Michael Kremer |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Doris Henne-Bruns, MD, Professor, Surgeon, General and Visceral Surgery, University Hospital of Ulm, Albert-Einstein-Allee 23, Ulm 89081, Germany. doris.henne-bruns@uniklinik-ulm.de |
| Key Words |
Esophageal cancer; Assessment of validity; Meta-analysis; CONSORT; Overall survival; |
| Core Tip |
The quality of single studies is crucial in order to perform valid meta-analyses that are often used as basis for guideline recommendations. We critically analysed a recent Cochrane meta-analysis that supports the use of preoperative chemotherapy for resectable thoracic esophageal cancer in order to improve overall survival. The most powerful included studies showed several inconsistencies according to the requirements of the Consort checklist for randomized controlled trials. After the exclusion of these studies from the meta-analysis, preoperative chemotherapy does not seem to result in an advantage in survival. We suggest a more critical appraisal regarding the validity of single studies. |
| Publish Date |
2019-12-31 07:02 |
| Citation |
Manzini G, Klotz U, Henne-Bruns D, Kremer M. Validity of studies suggesting preoperative chemotherapy for resectable thoracic esophageal cancer: A critical appraisal of randomized trials. World J Gastrointest Oncol 2020; 12(1): 113-123 |
| URL |
https://www.wjgnet.com/1948-5204/full/v12/i1/113.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v12.i1.113 |
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