| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Gao-Liang Zou, Shi Zuo, Shuang Lu, Rui-Han Hu, Yin-Ying Lu, Jing Yang, Kai-Sheng Deng, Ye-Ting Wu, Mao Mu, Juan-Juan Zhu, Jing-Zhang Zeng, Bao-Fang Zhang, Xian Wu, Xue-Ke Zhao and Hai-Yang Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81560104 |
| National Natural Science Foundation of China |
81860115 |
|
| Corresponding Author |
Xue-Ke Zhao, MD, PhD, Adjunct Professor, Department of Infectious Diseases, Affiliated Hospital of Guizhou Medical University, No. 28, Guiyi Road, Guiyang 550004, Guizhou Province, China. zhaoxueke1@163.com |
| Key Words |
Liver fibrosis; Bone morphogenetic protein; Transforming growth factor; Hepatic stellate cells; ; |
| Core Tip |
Liver fibrosis is the repair response of the liver to chronic injury. Its long-term persistence can eventually progress into cirrhosis or even liver cancer. Many cytokines and signaling pathways participate in the development and progression of liver fibrosis. The transforming growth factor-beta (TGF-β) superfamily member bone morphogenetic protein 7 (BMP7) is reported to have anti-fibrosis functions. This study observed changes in the dynamic expression of BMP7 during liver fibrosis, explored the relationship between BMP7 and TGF-β1, and further investigated the possible mechanism underlying the anti-liver fibrosis function of exogenous BMP7 using in vivo and in vitro experiments. This study demonstrated the prospect of exogenous BMP7 application as a potential anti-liver fibrosis drug. |
| Publish Date |
2019-08-14 13:31 |
| Citation |
Zou GL, Zuo S, Lu S, Hu RH, Lu YY, Yang J, Deng KS, Wu YT, Mu M, Zhu JJ, Zeng JZ, Zhang BF, Wu X, Zhao XK, Li HY. Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway. World J Gastroenterol 2019; 25(30): 4222-4234 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i30/4222.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i30.4222 |
