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Articles Published Processes
6/28/2019 12:22:27 PM | Browse: 1079 | Download: 1918
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Received |
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2019-03-22 02:00 |
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Peer-Review Started |
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2019-03-22 07:27 |
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To Make the First Decision |
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2019-04-11 08:57 |
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Return for Revision |
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2019-04-12 02:19 |
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Revised |
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2019-05-06 17:26 |
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Second Decision |
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2019-05-17 09:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-05-18 12:43 |
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Articles in Press |
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2019-05-18 12:43 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-06-27 08:20 |
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Publish the Manuscript Online |
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2019-06-28 12:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jose M Mato, Cristina Alonso, Mazen Noureddin and Shelly C Lu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jose M Mato, PhD, Director, Director, Professor, CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Technology Park of Bizkaia, Derio 48160, Bizkaia, Spain. director@cicbiogune.es |
| Key Words |
S-adenosylmethionine; Methionine adenosyltransferase; Lipid metabolism; Multiomics; Lipidomics; Nonalcoholic steatohepatitis; One-carbon metabolism; Very low-density lipoproteins; Steatosis; Precision medicine |
| Core Tip |
Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous and complex disease that is imprecisely diagnosed by liver biopsy. The advent of metabolomics has shown that NAFLD progression from simple steatosis to nonalcoholic steatohepatitis (NASH) associates with profound alterations in liver and serum lipidomic signatures that are good indicators of the disease’s development and progression. Lipidomics has also permitted the classification of NAFLD patients into different subtypes corresponding to the main alteration(s) leading, in each case, to the initiation and progression of NASH based on the identification of specific lipid signatures, opening the door to the development of precise NASH treatments. |
| Publish Date |
2019-06-28 12:22 |
| Citation |
Mato JM, Alonso C, Noureddin M, Lu SC. Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease. World J Gastroenterol 2019; 25(24): 3009-3020 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i24/3009.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i24.3009 |
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