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Articles Published Processes
8/7/2019 7:09:17 AM | Browse: 985 | Download: 2486
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Received |
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2019-03-29 01:06 |
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Peer-Review Started |
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2019-03-29 03:29 |
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To Make the First Decision |
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2019-06-10 08:17 |
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Return for Revision |
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2019-06-14 02:24 |
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Revised |
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2019-06-21 09:23 |
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Second Decision |
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2019-07-05 10:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-07-05 23:46 |
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Articles in Press |
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2019-07-05 23:46 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-08-05 08:38 |
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Publish the Manuscript Online |
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2019-08-07 07:09 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Honokiol-enhanced cytotoxic T lymphocyte activity against cholangiocarcinoma cells mediated by dendritic cells pulsed with damage-associated molecular patterns
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Arunya Jiraviriyakul, Worawat Songjang, Pongsathorn Kaewthet, Phachsita Tanawatkitichai, Punyapat Bayan and Sutatip Pongcharoen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Naresuan University |
R2559B102 |
| Naresuan University |
R2562C012 |
| Thailand Research Fund |
BRG6180010 |
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| Corresponding Author |
Sutatip Pongcharoen, PhD, Associate Professor, Division of Immunology, Department of Medicine, Faculty of Medicine, Naresuan University, Tapho District, Muang, Meaung 65000, Phitsanulok, Thailand. sutatipp@nu.ac.th |
| Key Words |
Cholangiocarcinoma; Dendritic cells; Honokiol; Damage-associated molecular patterns; Tumor cell lysates; |
| Core Tip |
We constructed dendritic cells (DCs) loaded with cell lysates derived from honokiol-treated cholangiocarcinoma tumour cells, with the aim of eliciting apoptosis in tumour cells and creating a broad array of tumour associated antigents in the form of dead and dying cells. Our data demonstrated that honokiol-treated cholangiocacinoma cells-derived tumour cell lysates could improve the fuctions for effector T lymphocytes in killing of the cancer cells. This suggested that honokiol enhanced the immunogenicity of cholangiocarcinoma antigens with increased effectiveness of DC-based vaccine formulation. |
| Publish Date |
2019-08-07 07:09 |
| Citation |
Jiraviriyakul A, Songjang W, Kaewthet P, Tanawatkitichai P, Bayan P, Pongcharoen S. Honokiol-enhanced cytotoxic T lymphocyte activity against cholangiocarcinoma cells mediated by dendritic cells pulsed with damage-associated molecular pattern. World J Gastroenterol 2019; 25(29): 3941-3955 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i29/3941.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i29.3941 |
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