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Articles Published Processes
8/21/2019 9:19:18 AM | Browse: 1163 | Download: 1979
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Received |
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2019-03-29 01:08 |
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Peer-Review Started |
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2019-03-29 04:03 |
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First Decision by Editorial Office Director |
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2019-06-10 06:19 |
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Return for Revision |
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2019-06-14 02:07 |
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Revised |
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2019-06-25 14:05 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-07-12 10:01 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-07-19 16:26 |
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Articles in Press |
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2019-07-19 16:26 |
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Edit the Manuscript by Language Editor |
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2019-07-30 04:10 |
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Typeset the Manuscript |
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2019-08-19 06:25 |
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Publish the Manuscript Online |
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2019-08-21 09:19 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
MiR-194 inactivates hepatic stellate cells and alleviates liver fibrosis by inhibiting AKT2
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Cheng Wu, Rong Chen, Xin Luo, Zheng-Hong Li, Zheng-Hong Luo and Ming-Yi Xu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
81600480 |
| the National Natural Science Foundation of China |
81570547 |
| the National Natural Science Foundation of China |
81770597 |
| the Development Program of China during the 13th Five-year Plan Period |
2017ZX10203202003005 |
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| Corresponding Author |
Ming-Yi Xu, MD, Chief Doctor, Professor, Department of Gastroenterology, Shanghai General Hospital, No. 100, Haining Road, Shanghai 200080, China. xumingyi2014@163.com |
| Key Words |
Hepatic stellate cells; Liver fibrosis; MicroRNA-194; AKT2; ; |
| Core Tip |
The expression of miR-194 was significantly downregulated in activated primary hepatic stellate cells (HSCs) from CCl4-treated mice, TGF-β1-treated LX2 cells and the livers of advanced fibrosis patients. MiR-194 significantly inhibited the expression of α-SMA, Col I, and cyclin D1 and suppressed the activation and proliferation of HSCs in vitro by repressing AKT2 signaling. MiR-194 could attenuate liver fibrosis progression to some extent in a mouse model. Reintroduction of miR-194 offered a possible therapeutic approach for ameliorating liver fibrosis. |
| Publish Date |
2019-08-21 09:19 |
| Citation |
Wu JC, Chen R, Luo X, Li ZH, Luo SZ, Xu MY. MiR-194 inactivates hepatic stellate cells and alleviates liver fibrosis by inhibiting AKT2. World J Gastroenterol 2016; 25(31): 4468-4480 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i31/4468.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i31.4468 |
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