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8/21/2019 9:19:18 AM | Browse: 771 | Download: 823
Publication Name World Journal of Gastroenterology
Manuscript ID 47875
Country/Territory China
Received
2019-03-29 01:08
Peer-Review Started
2019-03-29 04:03
To Make the First Decision
2019-06-10 08:20
Return for Revision
2019-06-14 02:07
Revised
2019-06-25 14:05
Second Decision
2019-07-12 10:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-19 16:26
Articles in Press
2019-07-19 16:26
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-07-30 04:10
Typeset the Manuscript
2019-08-19 06:25
Publish the Manuscript Online
2019-08-21 09:19
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title MiR-194 inactivates hepatic stellate cells and alleviates liver fibrosis by inhibiting AKT2
Manuscript Source Unsolicited Manuscript
All Author List Jun-Cheng Wu, Rong Chen, Xin Luo, Zheng-Hong Li, Zheng-Hong Luo and Ming-Yi Xu
ORCID
Author(s) ORCID Number
Jun-Cheng Wu http://orcid.org/0000-0002-8000-4380
Rong Chen http://orcid.org/0000-0002-7109-1750
Xin Luo http://orcid.org/0000-0001-5446-4079
Zheng-Hong Li http://orcid.org/0000-0003-2042-0718
Zheng-Hong Luo http://orcid.org/0000-0002-7643-3860
Ming-Yi Xu http://orcid.org/0000-0002-4834-3542
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China 81600480
the National Natural Science Foundation of China 81570547
the National Natural Science Foundation of China 81770597
the Development Program of China during the 13th Five-year Plan Period 2017ZX10203202003005
Corresponding Author Ming-Yi Xu, MD, Chief Doctor, Professor, Department of Gastroenterology, Shanghai General Hospital, No. 100, Haining Road, Shanghai 200080, China. xumingyi2014@163.com
Key Words Hepatic stellate cells; Liver fibrosis; MicroRNA-194; AKT2; ;
Core Tip The expression of miR-194 was significantly downregulated in activated primary hepatic stellate cells (HSCs) from CCl4-treated mice, TGF-β1-treated LX2 cells and the livers of advanced fibrosis patients. MiR-194 significantly inhibited the expression of α-SMA, Col I, and cyclin D1 and suppressed the activation and proliferation of HSCs in vitro by repressing AKT2 signaling. MiR-194 could attenuate liver fibrosis progression to some extent in a mouse model. Reintroduction of miR-194 offered a possible therapeutic approach for ameliorating liver fibrosis.
Publish Date 2019-08-21 09:19
Citation Wu JC, Chen R, Luo X, Li ZH, Luo SZ, Xu MY. MiR-194 inactivates hepatic stellate cells and alleviates liver fibrosis by inhibiting AKT2. World J Gastroenterol 2016; 25(31): 4468-4480
URL https://www.wjgnet.com/1007-9327/full/v25/i31/4468.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i31.4468
Full Article (PDF) WJG-25-4468.pdf
Full Article (Word) WJG-25-4468.docx
The ARRIVE Guidelines 47875-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 47875-Review_Edited.doc
Answering Reviewers 47875-Answering reviewers.pdf
Audio Core Tip 47875-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 47875-Conflict-of-interest statement.pdf
Copyright License Agreement 47875-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47875-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 47875-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47875-Language certificate.pdf
Supplementary Material 47875-Supplementary material.pdf
Peer-review Report 47875-Peer-review(s).pdf
Scientific Misconduct Check 47875-Scientific misconduct check.pdf
Scientific Editor Work List 47875-Scientific editor work list.pdf