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6/28/2019 12:22:27 PM | Browse: 220 | Download: 118
Publication Name World Journal of Gastroenterology
Manuscript ID 47929
Country/Territory United Kingdom
2019-03-30 04:35
Peer-Review Started
2019-04-01 07:18
To Make the First Decision
2019-04-17 00:18
Return for Revision
2019-04-17 02:54
2019-04-24 23:05
Second Decision
2019-05-17 09:09
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-18 12:42
Articles in Press
2019-05-18 12:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-06-27 08:28
Publish the Manuscript Online
2019-06-28 12:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Review
Article Title Immunotherapy for hepatocellular carcinoma: Current and future
Manuscript Source Invited Manuscript
All Author List Michael P Johnston and Salim I Khakoo
Author(s) ORCID Number
Michael P Johnston http://orcid.org/0000-0002-4704-8349
Salim I Khakoo http://orcid.org/0000-0002-4057-9091
Funding Agency and Grant Number
Corresponding author Salim I Khakoo, FRCP (C), MBBS, MD, Professor, Department of Clinical and Experimental Sciences, Faculty of Medicine, Southampton General Hospital, University of Southampton, Mailpoint 811, Level E South Academic Block, Tremona Road, Southampton SO16 6YD, United Kingdom. s.i.khakoo@soton.ac.uk
Keywords Adoptive cell therapy; Cancer vaccine; Checkpoint inhibitor; Hepatocellular carcinoma; Immunotherapy; Liver cancer; Oncolytic virus
Core Tip A significant proportion of patients with hepatocellular carcinoma (HCC) present with advanced disease, for which there are limited systemic therapeutic options. Complicating this, HCC often develops on a background of cirrhosis, which can preclude the use of certain cytotoxic agents. Immunotherapy has previously not been an available therapeutic option in HCC. However, checkpoint inhibition therapy was recently licensed as a second line option for advanced disease. Multiple other promising agents are in development which boost existing immune response or stimulate a de novo immune response. These agents are discussed herein.
Publish Date 2019-06-28 12:22
Citation Johnston MP, Khakoo SI. Immunotherapy for hepatocellular carcinoma: Current and future. World J Gastroenterol 2019; 25(24): 2977-2989
Url https://www.wjgnet.com/1007-9327/full/v25/i24/2977.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i24.2977
Full Article (PDF) WJG-25-2977.pdf
Full Article (Word) WJG-25-2977.docx
Manuscript File 47929-Review.docx
Answering Reviewers 47929-Answering reviewers.pdf
Audio Core Tip 47929-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47929-Conflict-of-interest statement.pdf
Copyright License Agreement 47929-Copyright license agreement.pdf
Peer-review Report 47929-Peer-review(s).pdf
Scientific Misconduct Check 47929-Scientific misconduct check.pdf
Scientific Editor Work List 47929-Scientific editor work list.pdf