ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Permissions |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Medicine, Research & Experimental |
Manuscript Type |
Basic Study |
Article Title |
Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-κB signaling pathways
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Chun-Xiao Li, Jian-Guo Gao, Xing-Yong Wan, Yi Chen, Cheng-Fu Xu, Ze-Min Feng, Hang Zeng, Yi-Ming Lin, Han Ma, Ping Xu, Chao-Hui Yu and You-Ming Li |
ORCID |
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Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81230012 |
National Natural Science Foundation of China |
8170054 |
National Natural Science Foundation of China |
81700511 |
Science Foundation of Health Bureau of Zhejiang Province |
2017183691 |
Natural Science Foundation of Zhejiang Province |
LY17H030006 |
Natural Science Foundation of Zhejiang Province |
LQ15H030002 |
Zhejiang Medical science and technology project |
2017193668 |
|
Corresponding Author |
You-Ming Li, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zlym@zju.edu.cn |
Key Words |
Allyl isothiocyanate; Nonalcoholic fatty liver disease; Hepatic steatosis; Liver inflammation; ; |
Core Tip |
Nonalcoholic fatty liver disease (NAFLD) is rapidly prevalent as a remarkable problem worldwide. We aimed to investigate therapeutic role of allyl isothiocyanate (AITC) in lipid accumulation and inflammation during NAFLD development in mice fed a high fat diet HFD and AML-12 cells treated with palmitate acid PA. Our study maybe for the first time demonstrates that AITC ameliorates hepatic steatosis and inflammation by activating the Sirt1)/AMPK and IKK/NF-κB signaling pathway. This study reveals role of AITC as a potential therapeutic agent for NAFLD. |
Publish Date |
2019-09-12 08:50 |
Citation |
Li CX, Gao JG, Wan XY, Chen Y, Xu CF, Feng ZM, Zeng H, Lin YM, Ma H, Xu P, Yu CH, Li YM. Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-κB signaling pathways. World J Gastroenterol 2019; 25(34): 5120-5133 |
URL |
https://www.wjgnet.com/1007-9327/full/v25/i34/5120.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v25.i34.5120 |