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9/12/2019 8:50:34 AM | Browse: 582 | Download: 1345
Publication Name World Journal of Gastroenterology
Manuscript ID 47970
Country/Territory China
Received
2019-04-02 00:22
Peer-Review Started
2019-04-02 08:03
To Make the First Decision
2019-05-27 01:03
Return for Revision
2019-05-27 06:21
Revised
2019-06-12 13:48
Second Decision
2019-06-21 10:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-26 04:44
Articles in Press
2019-06-26 04:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-07-13 18:49
Typeset the Manuscript
2019-09-11 08:04
Publish the Manuscript Online
2019-09-12 08:50
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Basic Study
Article Title Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-κB signaling pathways
Manuscript Source Unsolicited Manuscript
All Author List Chun-Xiao Li, Jian-Guo Gao, Xing-Yong Wan, Yi Chen, Cheng-Fu Xu, Ze-Min Feng, Hang Zeng, Yi-Ming Lin, Han Ma, Ping Xu, Chao-Hui Yu and You-Ming Li
ORCID
Author(s) ORCID Number
Chun-Xiao Li http://orcid.org/0000-0003-2433-2408
Jian-Guo Gao http://orcid.org/0000-0002-9414-5395
Xing-Yong Wan http://orcid.org/0000-0002-2578-1291
Yi Chen http://orcid.org/0000-0002-5532-6062
Cheng-Fu Xu http://orcid.org/0000-0002-6172-1253
Ze-Min Feng http://orcid.org/0000-0003-3419-0247
Hang Zeng http://orcid.org/0000-0001-6742-1713
Yi-Ming Lin http://orcid.org/0000-0001-5903-4035
Han Ma http://orcid.org/0000-0001-9985-3035
Ping Xu http://orcid.org/0000-0002-4430-719X
Chao-Hui Yu http://orcid.org/0000-0003-4842-3646
You-Ming Li http://orcid.org/0000-0001-9279-2903
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81230012
National Natural Science Foundation of China 8170054
National Natural Science Foundation of China 81700511
Science Foundation of Health Bureau of Zhejiang Province 2017183691
Natural Science Foundation of Zhejiang Province LY17H030006
Natural Science Foundation of Zhejiang Province LQ15H030002
Zhejiang Medical science and technology project 2017193668
Corresponding Author You-Ming Li, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. zlym@zju.edu.cn
Key Words Allyl isothiocyanate; Nonalcoholic fatty liver disease; Hepatic steatosis; Liver inflammation; ;
Core Tip Nonalcoholic fatty liver disease (NAFLD) is rapidly prevalent as a remarkable problem worldwide. We aimed to investigate therapeutic role of allyl isothiocyanate (AITC) in lipid accumulation and inflammation during NAFLD development in mice fed a high fat diet HFD and AML-12 cells treated with palmitate acid PA. Our study maybe for the first time demonstrates that AITC ameliorates hepatic steatosis and inflammation by activating the Sirt1)/AMPK and IKK/NF-κB signaling pathway. This study reveals role of AITC as a potential therapeutic agent for NAFLD.
Publish Date 2019-09-12 08:50
Citation Li CX, Gao JG, Wan XY, Chen Y, Xu CF, Feng ZM, Zeng H, Lin YM, Ma H, Xu P, Yu CH, Li YM. Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-κB signaling pathways. World J Gastroenterol 2019; 25(34): 5120-5133
URL https://www.wjgnet.com/1007-9327/full/v25/i34/5120.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i34.5120
Full Article (PDF) WJG-25-5120.pdf
Full Article (Word) WJG-25-5120.docx
The ARRIVE Guidelines 47970-The-ARRIVE-Guidelines-revision.pdf
Manuscript File Confirmed version- FP6896_de26_CE1MS-edit2.docx
Answering Reviewers 47970-Answering reviewers.pdf
Audio Core Tip 47970-Audio core tip.mp3
Biostatistics Review Certificate 47970-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47970-Conflict-of-interest statement.pdf
Copyright License Agreement 47970-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47970-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 47970-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 47970-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47970-Language certificate.pdf
Supplementary Material 47970-Supplementary material.pdf
Peer-review Report 47970-Peer-review(s).pdf
Scientific Misconduct Check 47970-Google-MA RY-1.png
Scientific Misconduct Check 47970-Scientific misconduct check.pdf
Scientific Editor Work List 47970-Scientific editor work list.pdf