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8/14/2019 1:31:33 PM | Browse: 78 | Download: 89
Publication Name World Journal of Gastroenterology
Manuscript ID 48060
Country/Territory Italy
2019-04-08 00:53
Peer-Review Started
2019-04-08 03:38
To Make the First Decision
2019-05-31 00:29
Return for Revision
2019-05-31 02:05
2019-06-20 13:22
Second Decision
2019-07-01 09:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-03 01:10
Articles in Press
2019-07-03 01:10
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-07-15 21:43
Typeset the Manuscript
2019-08-07 06:42
Publish the Manuscript Online
2019-08-14 13:31
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Minireviews
Article Title Reduced lysosomal acid lipase activity: A new marker of liver disease severity across the clinical continuum of non-alcoholic fatty liver disease?
Manuscript Source Invited Manuscript
All Author List Francesco Baratta, Daniele Pastori, Domenico Ferro, Giovanna Carluccio, Giulia Tozzi, Francesco Angelico, Francesco Violi and Maria Del Ben
Author(s) ORCID Number
Francesco Baratta http://orcid.org/0000-0003-1708-272X
Daniele Pastori http://orcid.org/0000-0001-6357-5213
Domenico Ferro http://orcid.org/0000-0001-5222-4477
Giovanna Carluccio http://orcid.org/0000-0003-3340-5621
Giulia Tozzi http://orcid.org/0000-0002-1745-2797
Francesco Angelico http://orcid.org/0000-0002-9372-3923
Francesco Violi http://orcid.org/0000-0002-6610-7068
Maria Del Ben http://orcid.org/0000-0003-1199-8454
Funding Agency and Grant Number
Corresponding author Francesco Angelico, MD, Associate Professor, Professor, Department of Public Health and Infectious Diseases, Sapienza University, viale del Policlinico 155, Rome 00161, Italy. francesco.angelico@uniroma1.it
Keywords Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Lysosomal acid lipase; Cirrhosis; Wolman disease; Cholesterol ester storage disease
Core Tip Reduced lysosomal acid lipase (LAL) activity promotes an increased multi-organ lysosomal cholesterol esters storage, as observed in two recessive autosomal genetic diseases, Wolman disease and Cholesterol ester storage disease. A less severe and non-genetic reduction of LAL activity has been reported in children and adults with non-alcoholic fatty liver disease (NAFLD). Patients with NAFLD show a significant, progressive reduction of LAL activity from simple steatosis, to non-alcoholic steatohepatitis and cryptogenic cirrhosis. In the future, modulation of LAL activity may become a possible new therapeutic target for patients with more advanced forms of NAFLD and represent a possible new marker of disease severity.
Publish Date 2019-08-14 13:31
Citation Francesco B, Daniele P, Domenico F, Giovanna C, Giulia T, Francesco A, Francesco V, Maria DB. Reduced lysosomal acid lipase activity: A new marker of liver disease severity across the clinical continuum of non-alcoholic fatty liver disease? World J Gastroenterol 2019; 25(30): 4172-4180
Url https://www.wjgnet.com/1007-9327/full/v25/i30/4172.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i30.4172
Full Article (PDF) WJG-25-4172.pdf
Full Article (Word) WJG-25-4172.docx
Manuscript File FP6910_de5_CE1MS-edit2.docx
Answering Reviewers 48060-Answering reviewers.pdf
Audio Core Tip 48060-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 48060-Conflict-of-interest statement.pdf
Copyright License Agreement 48060-Copyright License Agreement.pdf
Peer-review Report 48060-Peer-review(s).pdf
Scientific Misconduct Check 48060-Google-MA RY-1.png
Scientific Misconduct Check 48060-Google-MA RY-2.png
Scientific Misconduct Check 48060-Scientific misconduct check.pdf
Scientific Editor Work List 48060-Scientific editor work list.pdf