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Articles Published Processes
8/14/2019 1:31:33 PM | Browse: 874 | Download: 1467
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Received |
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2019-04-08 00:53 |
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Peer-Review Started |
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2019-04-08 03:38 |
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To Make the First Decision |
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2019-05-31 00:29 |
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Return for Revision |
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2019-05-31 02:05 |
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Revised |
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2019-06-20 13:22 |
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Second Decision |
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2019-07-01 09:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-07-03 01:10 |
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Articles in Press |
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2019-07-03 01:10 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-07-15 21:43 |
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Typeset the Manuscript |
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2019-08-07 06:42 |
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Publish the Manuscript Online |
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2019-08-14 13:31 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Reduced lysosomal acid lipase activity: A new marker of liver disease severity across the clinical continuum of non-alcoholic fatty liver disease?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Francesco Baratta, Daniele Pastori, Domenico Ferro, Giovanna Carluccio, Giulia Tozzi, Francesco Angelico, Francesco Violi and Maria Del Ben |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Francesco Angelico, MD, Associate Professor, Professor, Department of Public Health and Infectious Diseases, Sapienza University, viale del Policlinico 155, Rome 00161, Italy. francesco.angelico@uniroma1.it |
| Key Words |
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Lysosomal acid lipase; Cirrhosis; Wolman disease; Cholesterol ester storage disease |
| Core Tip |
Reduced lysosomal acid lipase (LAL) activity promotes an increased multi-organ lysosomal cholesterol esters storage, as observed in two recessive autosomal genetic diseases, Wolman disease and Cholesterol ester storage disease. A less severe and non-genetic reduction of LAL activity has been reported in children and adults with non-alcoholic fatty liver disease (NAFLD). Patients with NAFLD show a significant, progressive reduction of LAL activity from simple steatosis, to non-alcoholic steatohepatitis and cryptogenic cirrhosis. In the future, modulation of LAL activity may become a possible new therapeutic target for patients with more advanced forms of NAFLD and represent a possible new marker of disease severity. |
| Publish Date |
2019-08-14 13:31 |
| Citation |
Francesco B, Daniele P, Domenico F, Giovanna C, Giulia T, Francesco A, Francesco V, Maria DB. Reduced lysosomal acid lipase activity: A new marker of liver disease severity across the clinical continuum of non-alcoholic fatty liver disease? World J Gastroenterol 2019; 25(30): 4172-4180 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i30/4172.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i30.4172 |
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