Publication Name	World Journal of Gastroenterology
Manuscript ID	4821
Country	China

Received	2013-07-25 10:32
Peer-Review Started	2013-07-25 16:32
To Make the First Decision	2013-08-21 18:27
Return for Revision	2013-09-16 11:25
Revised	2013-09-01 21:51
Second Decision	2013-09-16 18:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-09-17 06:57
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-11-08 08:53
Publish the Manuscript Online	2013-11-16 18:29

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Stages based molecular mechanisms for generating cholangiocytes from liver stem/progenitor cells
Manuscript Source	Invited Manuscript
All Author List	Wei-Hui Liu, Li-Na Ren, Tao Chen, Li-Ye Liu and Li-Jun Tang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81302168 National Natural Science Foundation of China 81172061 National Natural Science Foundation of China 81370016 National Natural Science Foundation of China 81170419
Corresponding Author	Li-Jun Tang, Professor, General Surgery Center of PLA; Chengdu Military General Hospital, Chengdu 610083, Sichuan Province, China. whjtlj1251@163.com
Key Words	Liver stem/progenitor cells; Cholangiocytes; Biliary differentiation; Unbalanced distribution of materials; Cell therapy
Core Tip	After liver stem/progenitor cells (LSPCs) are isolated by different groups from both fetal and adult livers, it is urgent to decide the cell fates of LSPCs. Especially, it is found that the core issue for LSPCs application lies in their accurate differentiation. Because there are lots of literatures concentrating on self-renewal and hepatic differentiation of LSPCs, in this review, we mainly summarize the molecular mechanisms for controlling other cell fates of LSPCs, especially differentiation into cholangiocytes. For biliary differentiation, we propose that it is a gradually progressing process consisting of three main steps: initiation, progression and accomplishment.
Publish Date	2013-11-16 18:29
Citation	Liu WH, Ren LN, Chen T, Liu LY, Tang LJ. Stages based molecular mechanisms for generating cholangiocytes from liver stem/progenitor cells. World J Gastroenterol 2013; 19(41): 7032-7041
URL	http://www.wjgnet.com/1007-9327/full/v19/i41/7032.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i41.7032

Full Article (PDF)	WJG-19-7032.pdf
Manuscript File	4821-Review.doc
Answering Reviewers	4821-Answering Reviewers.pdf
Copyright License Agreement	4821-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	4821-Language certificate.pdf
Peer-review Report	4821-Peer review(s).pdf
Scientific Editor Work List	4821-Scientific editor work list.doc