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12/30/2019 1:55:29 AM | Browse: 616 | Download: 1092
Publication Name World Journal of Stem Cells
Manuscript ID 48245
Country/Territory South Korea
Received
2019-04-12 07:19
Peer-Review Started
2019-04-14 09:37
To Make the First Decision
2019-05-28 02:57
Return for Revision
2019-06-11 07:34
Revised
2019-08-16 08:48
Second Decision
2019-09-24 08:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-26 20:53
Articles in Press
2019-09-26 20:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-10-23 19:43
Typeset the Manuscript
2019-12-02 01:46
Publish the Manuscript Online
2019-12-30 01:55
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Basic Study
Article Title Generation of induced secretome from adipose-derived stem cells specialized for disease-specific treatment: An experimental mouse model
Manuscript Source Unsolicited Manuscript
All Author List Ok-Hee Kim, Ha-Eun Hong, Bong Jun Kwak, Ho Joong Choi, Kee-Hwan Kim, Joseph Ahn, Sang Chul Lee, Say-June Kim and Haeyeon Seo
ORCID
Author(s) ORCID Number
Ok-Hee Kim http://orcid.org/0000-0002-9204-2587
Ha-Eun Hong http://orcid.org/0000-0002-4361-4809
Bong Jun Kwak http://orcid.org/0000-0003-2409-9386
Ho Joong Choi http://orcid.org/0000-0002-0862-098X
Kee-Hwan Kim http://orcid.org/0000-0001-6219-6027
Joseph Ahn http://orcid.org/0000-0001-8528-4919
Sang Chul Lee http://orcid.org/0000-0002-8681-7059
Say-June Kim http://orcid.org/0000-0001-5171-4837
Haeyeon Seo http://orcid.org/0000-0003-2992-8112
Funding Agency and Grant Number
Funding Agency Grant Number
National Research Foundation of Korea 2015R1C1A1A02036931
Corresponding Author Say-June Kim, MD, PhD, Professor, Surgeon, Department of Surgery, Division of Hepato-biliary Pancreatic Surgery, Seoul St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, South Korea. sayjunekim@gmail.com
Key Words Adipose-derived stem cells; Disease-specificity; Mesenchymal stem cells; Secretome; Peroxiredoxin-1; Thioacetamide
Core Tip Appropriate stimulation of adipose-derived stem cells (ASCs) with thioacetamide (TAA) led to the production of secretome enriched with proteins, especially peroxiredoxin-1, with higher antioxidant activity. Free radicals are principal pathogenic agents in the pathogenesis of TAA-induced hepatic injury. The TAA-induced secretome was superior to the naïve secretome in restoring hepatic function while minimizing inflammatory processes in mice with TAA-induced hepatic failure. However, it was not so effective in the mice with partial hepatectomy, suggestive of disease-specificity. Our results suggest that appropriate stimulation of ASCs with pathogenic agents can lead to the production of secretome specialized for protecting against the pathogen.
Publish Date 2019-12-30 01:55
Citation Kim OH, Hong HE, Seo H, Kwak BJ, Choi HJ, Kim KH, Ahn J, Lee SC, and Kim SJ. Generation of induced secretome from adipose-derived stem cells specialized for disease-specific treatment: an experimental mouse model. World J Stem Cells 2020; 12(1): 70-86
URL https://www.wjgnet.com/1948-0210/full/v12/i1/70.htm
DOI https://dx.doi.org/10.4252/wjsc.v12.i1.70
Full Article (PDF) WJSC-12-70.pdf
Full Article (Word) WJSC-12-70.docx
Manuscript File FP7044_ce16_CE1MS_edit2.docx
Answering Reviewers 48245-Answering reviewers.pdf
Audio Core Tip 48245-Audio core tip.mp3
Biostatistics Review Certificate 48245-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 48245-Conflict-of-interest statement.pdf
Copyright License Agreement 48245-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 48245-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 48245-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 48245-Language certificate.pdf
Peer-review Report 48245-Peer-review(s).pdf
Scientific Misconduct Check 48245-Scientific misconduct check.pdf
Scientific Editor Work List 48245-Scientific editor work list.pdf