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Articles Published Processes
12/30/2019 1:55:29 AM | Browse: 1204 | Download: 2563
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Received |
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2019-04-12 07:19 |
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Peer-Review Started |
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2019-04-14 09:37 |
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First Decision by Editorial Office Director |
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2019-05-16 14:03 |
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Return for Revision |
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2019-06-11 07:34 |
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Revised |
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2019-08-16 08:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-09-24 08:27 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-09-26 20:53 |
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Articles in Press |
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2019-09-26 20:53 |
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Edit the Manuscript by Language Editor |
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2019-10-23 19:43 |
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Typeset the Manuscript |
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2019-12-02 01:46 |
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Publish the Manuscript Online |
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2019-12-30 01:55 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Generation of induced secretome from adipose-derived stem cells specialized for disease-specific treatment: An experimental mouse model
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ok-Hee Kim, Ha-Eun Hong, Bong Jun Kwak, Ho Joong Choi, Kee-Hwan Kim, Joseph Ahn, Sang Chul Lee, Say-June Kim and Haeyeon Seo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Research Foundation of Korea |
2015R1C1A1A02036931 |
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| Corresponding Author |
Say-June Kim, MD, PhD, Professor, Surgeon, Department of Surgery, Division of Hepato-biliary Pancreatic Surgery, Seoul St. Mary’s Hospital, College of Medicine, the Catholic University of Korea, 222, Banpo-daero, Seocho-gu, Seoul 06591, South Korea. sayjunekim@gmail.com |
| Key Words |
Adipose-derived stem cells; Disease-specificity; Mesenchymal stem cells; Secretome; Peroxiredoxin-1; Thioacetamide |
| Core Tip |
Appropriate stimulation of adipose-derived stem cells (ASCs) with thioacetamide (TAA) led to the production of secretome enriched with proteins, especially peroxiredoxin-1, with higher antioxidant activity. Free radicals are principal pathogenic agents in the pathogenesis of TAA-induced hepatic injury. The TAA-induced secretome was superior to the naïve secretome in restoring hepatic function while minimizing inflammatory processes in mice with TAA-induced hepatic failure. However, it was not so effective in the mice with partial hepatectomy, suggestive of disease-specificity. Our results suggest that appropriate stimulation of ASCs with pathogenic agents can lead to the production of secretome specialized for protecting against the pathogen. |
| Publish Date |
2019-12-30 01:55 |
| Citation |
Kim OH, Hong HE, Seo H, Kwak BJ, Choi HJ, Kim KH, Ahn J, Lee SC, and Kim SJ. Generation of induced secretome from adipose-derived stem cells specialized for disease-specific treatment: an experimental mouse model. World J Stem Cells 2020; 12(1): 70-86
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| URL |
https://www.wjgnet.com/1948-0210/full/v12/i1/70.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i1.70 |
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