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Articles Published Processes
10/21/2019 9:37:00 AM | Browse: 726 | Download: 1508
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Received |
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2019-04-28 00:31 |
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Peer-Review Started |
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2019-04-28 07:24 |
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To Make the First Decision |
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2019-07-22 03:44 |
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Return for Revision |
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2019-07-24 02:02 |
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Revised |
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2019-08-16 19:42 |
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Second Decision |
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2019-09-12 09:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-09-13 04:20 |
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Articles in Press |
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2019-09-13 04:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-10-18 01:15 |
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Publish the Manuscript Online |
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2019-10-21 09:37 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Mohamed T Khayyal, Walaa Wadie, Enas A Abd El-Haleim, Kawkab A Ahmed, Olaf Kelber, Ramy M Ammar and Heba Abdel-Aziz |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mohamed T Khayyal, PhD, Professor, Department of Pharmacology, Faculty of Pharmacy, Cairo University, Kasr-El-Aini Street, Cairo 11562, Egypt. mtkhayyal@gmail.com |
| Key Words |
Diclofenac; STW 5; Omeprazole; Gastro-intestinal lesions; Inflammation; |
| Core Tip |
The herbal preparation STW 5, clinically used in functional dyspepsia and irritable bowel syndrome, was compared to omeprazole in protecting against diclofenac- induced gastro-duodenal lesions in rats. Both drugs were effective in preventing changes in the level of inflammatory mediators (tumor necrosis factor α, interleukins-1β and 10), in the level of the oxidative stress enzyme, heme oxygenase-1, and the apoptotic regulator (B-cell lymphoma 2) in both stomach and duodenum. However, STW 5 was more effective than omeprazole in protecting against the histological damage. The results emphasize the potential usefulness of STW 5 and its superiority over omeprazole in protecting against gastro-duodenal lesions induced by nonsteroidal anti-inflammatory drugs. |
| Publish Date |
2019-10-21 09:37 |
| Citation |
Khayyal MT, Wadie W, Abd El-Haleim EA, Ahmed KA, Kelber O, Ammar RM, Abdel-Aziz H. STW 5 is effective against nonsteroidal anti-inflammatory drugs induced gastro-duodenal lesions in rats. World J Gastroenterol 2019; 25(39): 5926-5935 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i39/5926.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i39.5926 |
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