Publication Name	World Journal of Gastroenterology
Manuscript ID	48424
Country	Finland

Received	2019-04-25 05:34
Peer-Review Started	2019-04-25 08:01
To Make the First Decision	2019-05-27 00:40
Return for Revision	2019-05-31 00:53
Revised	2019-06-07 11:04
Second Decision	2019-07-09 09:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-07-19 15:52
Articles in Press	2019-07-19 15:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-08-20 07:03
Publish the Manuscript Online	2019-08-21 09:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance
Manuscript Source	Invited Manuscript
All Author List	Anne E Tuomisto, Markus J Makinen and Juha P Väyrynen
ORCID	Author(s) ORCID Number Anne E Tuomisto http://orcid.org/0000-0002-9949-1887 Markus J Makinen http://orcid.org/0000-0002-9200-4118 Juha P Väyrynen http://orcid.org/0000-0002-8683-2996
Funding Agency and Grant Number
Corresponding Author	Anne E Tuomisto, PhD, Research Scientist, Department of Pathology, Oulu University Hospital and Medical Research Center Oulu, POB 21, Oulu 90220, Finland. anne.tuomisto@oulu.fi
Key Words	Colorectal cancer; Inflammation; Prognosis; Cytokine; Chemokine; C-reactive protein
Core Tip	Increasing evidence indicates that systemic inflammation has wide-ranging effects on colorectal cancer (CRC) pathogenesis, spanning from supporting primary tumor growth by promoting tumor cell proliferation to helping angiogenesis by enhancing the availability of pro-angiogenic molecules, to suppressing anti-tumor immunity by recruiting anti-inflammatory cell types, and to shaping pre-metastatic niches to promote subsequent metastasis. Systemic inflammatory biomarkers, such as circulating acute phase proteins, cytokines, exosomes, and leukocytes, may help to classify CRC patients into useful prognostic categories. However, further larger-scale studies are needed to determine optimal marker combinations for selecting patients to receive specific treatments.
Publish Date	2019-08-21 09:19
Citation	Tuomisto AE, Mäkinen MJ, Väyrynen JP. Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance. World J Gastroenterol 2019; 25(31): 4383-4404
URL	https://www.wjgnet.com/1007-9327/full/v25/i31/4383.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i31.4383

Full Article (PDF)	WJG-25-4383.pdf
Full Article (Word)	WJG-25-4383.docx
Manuscript File	48424-Review.docx
Answering Reviewers	48424-Answering reviewers.pdf
Audio Core Tip	48424-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	48424-Conflict-of-interest statement.pdf
Copyright License Agreement	48424-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	48424-Language certificate.pdf
Peer-review Report	48424-Peer-review(s).pdf
Scientific Misconduct Check	48424-Scientific misconduct check.pdf
Scientific Editor Work List	48424-Scientific editor work list.pdf