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8/21/2019 9:19:18 AM | Browse: 213 | Download: 209
Publication Name World Journal of Gastroenterology
Manuscript ID 48424
Country/Territory Finland
2019-04-25 05:34
Peer-Review Started
2019-04-25 08:01
To Make the First Decision
2019-05-27 00:40
Return for Revision
2019-05-31 00:53
2019-06-07 11:04
Second Decision
2019-07-09 09:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-19 15:52
Articles in Press
2019-07-19 15:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-08-20 07:03
Publish the Manuscript Online
2019-08-21 09:19
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance
Manuscript Source Invited Manuscript
All Author List Anne E Tuomisto, Markus J Makinen and Juha P Väyrynen
Author(s) ORCID Number
Anne E Tuomisto http://orcid.org/0000-0002-9949-1887
Markus J Makinen http://orcid.org/0000-0002-9200-4118
Juha P Väyrynen http://orcid.org/0000-0002-8683-2996
Funding Agency and Grant Number
Corresponding author Anne E Tuomisto, PhD, Research Scientist, Department of Pathology, Oulu University Hospital and Medical Research Center Oulu, POB 21, Oulu 90220, Finland. anne.tuomisto@oulu.fi
Keywords Colorectal cancer; Inflammation; Prognosis; Cytokine; Chemokine; C-reactive protein
Core Tip Increasing evidence indicates that systemic inflammation has wide-ranging effects on colorectal cancer (CRC) pathogenesis, spanning from supporting primary tumor growth by promoting tumor cell proliferation to helping angiogenesis by enhancing the availability of pro-angiogenic molecules, to suppressing anti-tumor immunity by recruiting anti-inflammatory cell types, and to shaping pre-metastatic niches to promote subsequent metastasis. Systemic inflammatory biomarkers, such as circulating acute phase proteins, cytokines, exosomes, and leukocytes, may help to classify CRC patients into useful prognostic categories. However, further larger-scale studies are needed to determine optimal marker combinations for selecting patients to receive specific treatments.
Publish Date 2019-08-21 09:19
Citation Tuomisto AE, Mäkinen MJ, Väyrynen JP. Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance. World J Gastroenterol 2019; 25(31): 4383-4404
Url https://www.wjgnet.com/1007-9327/full/v25/i31/4383.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i31.4383
Full Article (PDF) WJG-25-4383.pdf
Full Article (Word) WJG-25-4383.docx
Manuscript File 48424-Review.docx
Answering Reviewers 48424-Answering reviewers.pdf
Audio Core Tip 48424-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 48424-Conflict-of-interest statement.pdf
Copyright License Agreement 48424-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 48424-Language certificate.pdf
Peer-review Report 48424-Peer-review(s).pdf
Scientific Misconduct Check 48424-Scientific misconduct check.pdf
Scientific Editor Work List 48424-Scientific editor work list.pdf