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Articles Published Processes
8/21/2019 9:19:18 AM | Browse: 1063 | Download: 1606
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Received |
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2019-04-25 05:34 |
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Peer-Review Started |
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2019-04-25 08:01 |
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To Make the First Decision |
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2019-05-27 00:40 |
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Return for Revision |
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2019-05-31 00:53 |
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Revised |
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2019-06-07 11:04 |
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Second Decision |
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2019-07-09 09:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-07-19 15:52 |
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Articles in Press |
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2019-07-19 15:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-08-20 07:03 |
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Publish the Manuscript Online |
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2019-08-21 09:19 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Anne E Tuomisto, Markus J Makinen and Juha P Väyrynen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Anne E Tuomisto, PhD, Research Scientist, Department of Pathology, Oulu University Hospital and Medical Research Center Oulu, POB 21, Oulu 90220, Finland. anne.tuomisto@oulu.fi |
| Key Words |
Colorectal cancer; Inflammation; Prognosis; Cytokine; Chemokine; C-reactive protein |
| Core Tip |
Increasing evidence indicates that systemic inflammation has wide-ranging effects on colorectal cancer (CRC) pathogenesis, spanning from supporting primary tumor growth by promoting tumor cell proliferation to helping angiogenesis by enhancing the availability of pro-angiogenic molecules, to suppressing anti-tumor immunity by recruiting anti-inflammatory cell types, and to shaping pre-metastatic niches to promote subsequent metastasis. Systemic inflammatory biomarkers, such as circulating acute phase proteins, cytokines, exosomes, and leukocytes, may help to classify CRC patients into useful prognostic categories. However, further larger-scale studies are needed to determine optimal marker combinations for selecting patients to receive specific treatments. |
| Publish Date |
2019-08-21 09:19 |
| Citation |
Tuomisto AE, Mäkinen MJ, Väyrynen JP. Systemic inflammation in colorectal cancer: Underlying factors, effects, and prognostic significance. World J Gastroenterol 2019; 25(31): 4383-4404 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i31/4383.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i31.4383 |
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