Publication Name	World Journal of Gastroenterology
Manuscript ID	48428
Country	China

Received	2019-04-17 23:57
Peer-Review Started	2019-04-18 06:48
To Make the First Decision	2019-06-17 01:17
Return for Revision	2019-06-17 07:21
Revised	2019-07-18 18:04
Second Decision	2019-08-02 10:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-08-07 09:39
Articles in Press	2019-08-07 09:39
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-08-12 01:06
Typeset the Manuscript	2019-08-19 06:40
Publish the Manuscript Online	2019-08-21 09:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Basic Study
Article Title	Analysis of unfavorable prognostic biomarker of adenoma polyposis coli in period-T4 gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Weibo Du, Chenhong Lin and Wenbiao Chen
ORCID	Author(s) ORCID Number Weibo Du http://orcid.org/0000-0001-5779-6159 Chenhong Lin http://orcid.org/0000-0002-9730-5614 Wenbiao Chen http://orcid.org/0000-0002-1028-6319
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81571953
Corresponding Author	Wenbiao Chen, PhD, Doctor, Doctor, Postdoctoral Fellow, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou , Zhejiang, Hangzhou 310003, Zhejiang Province, China. chanwenbiao@sina.com
Key Words	Adenoma polyposis coli; Gastric cancer; Prognosis; mRNA; miRNA; Methylation
Core Tip	We found that high expression of adenoma polyposis coli (APC) was associated with poor prognosis in period-T4 gastric cancer (GC) patients. There was different expression of genes, miRNA and DNA methylation between high expression of APC (APChigh) and low expression of APC (APClow) groups. The APChigh associated with different expression of genes, miRNA and DNA methylation could contributed to the poor prognosis in period-T4 GC patients, and were involved with the pathogenesis of GC. We emphasized the APC, which could be used as novel biomarker to be applied to clinical diagnosis, therapy, and assessment of prognosis in period-T4 GC patients, as well as further research on the pathogenesis of GC.
Publish Date	2019-08-21 09:19
Citation	Du WB, Lin CH, Chen WB. Analysis of unfavorable prognostic biomarker of adenoma polyposis coli in period-T4 gastric cancer. World J Gastroenterol 2019; 25(31): 4452-4467
URL	https://www.wjgnet.com/1007-9327/full/v25/i31/4452.htm
DOI	https://dx.doi.org/10.3748/wjg.v25.i31.4452

Full Article (PDF)	WJG-25-4452.pdf
Full Article (Word)	WJG-25-4452.docx
The ARRIVE Guidelines	48428-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	48428-Review_Edited.docx
Answering Reviewers	48428-Answering reviewers.pdf
Audio Core Tip	48428-Audio core tip.mp3
Biostatistics Review Certificate	48428-Biostatistics statement .pdf
Conflict-of-Interest Disclosure Form	48428-Conflict-of-interest statement.pdf
Copyright License Agreement	48428-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	48428-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	48428-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	48428-Language certificate.pdf
Supplementary Material	48428-Supplementary material.pdf
Peer-review Report	48428-Peer-review(s).pdf
Scientific Misconduct Check	48428-Bing-MA RY-2.png
Scientific Misconduct Check	48428-Scientific misconduct check.pdf
Scientific Editor Work List	48428-Scientific editor work list.pdf
CrossCheck Report	48428-CrossCheck report.pdf