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Articles Published Processes
9/7/2019 4:43:36 AM | Browse: 1497 | Download: 3448
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Received |
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2019-04-26 01:29 |
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Peer-Review Started |
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2019-04-26 01:58 |
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First Decision by Editorial Office Director |
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2019-05-24 12:12 |
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Return for Revision |
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2019-05-31 02:45 |
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Revised |
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2019-06-28 08:21 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-07-12 10:05 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-07-19 15:50 |
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Articles in Press |
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2019-07-19 15:50 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-09-04 03:16 |
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Publish the Manuscript Online |
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2019-09-07 04:43 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Michelle L Boland, Denise Oró, Kirstine S Tølbøl, Sebastian T Thrane, Jens Christian Nielsen, Taylor S Cohen, David E Tabor, Fiona Fernandes, Andrey Tovchigrechko, Sanne S Veidal, Paul Warrener, Bret R Sellman, Jacob Jelsing, Michael Feigh, Niels Vrang, James L Trevaskis and Henrik H Hansen |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Innovation Fund Denmark |
5016-00168B |
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| Corresponding Author |
Henrik H Hansen, PhD, Senior Scientist, Pharmacology, Gubra, Hørsholm Kongevej 11B, Hoersholm DK-2970, Denmark. hbh@gubra.dk |
| Key Words |
Non-alcoholic steatohepatitis; High-fat diet; Mouse model; Histopathology; Fibrosis; Liver biopsy |
| Core Tip |
The trans-fat containing amylin liver non-alcoholic steatohepatitis (NASH) (AMLN) diet has been extensively validated in mice for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH. A recent ban on trans-fats as food additive prompted the development of a new diet with similar disease-inducing properties as the AMLN diet. Here, we introduce a trans-fat-free diet high in palm oil (Gubra amylin NASH, GAN diet) that promotes a highly similar phenotype of biopsy-confirmed fibrotic NASH in both ob/ob and C57BL/6J mice, highlighting the suitability of GAN diet-induced obese mouse models of biopsy-confirmed NASH for the characterization of novel drug therapies for NASH. |
| Publish Date |
2019-09-07 04:43 |
| Citation |
Boland ML, Oró D, Tølbøl KS, Thrane ST, Nielsen JC, Cohen TS, Tabor DE, Fernandes F, Tovchigrechko A, Veidal SS, Warrener P, Sellman BR, Jelsing J, Feigh M, Vrang N, Trevaskis JL, Hansen HH. Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source. World J Gastroenterol 2019; 25(33): 4904-4920
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| URL |
https://www.wjgnet.com/1007-9327/full/v25/i33/4904.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i33.4904 |
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