BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
9/7/2019 4:43:36 AM | Browse: 107 | Download: 196
Publication Name World Journal of Gastroenterology
Manuscript ID 48566
Country/Territory Denmark
2019-04-26 01:29
Peer-Review Started
2019-04-26 01:58
To Make the First Decision
2019-05-27 00:33
Return for Revision
2019-05-31 02:45
2019-06-28 08:21
Second Decision
2019-07-12 10:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-19 15:50
Articles in Press
2019-07-19 15:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-09-04 03:16
Publish the Manuscript Online
2019-09-07 04:43
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source
Manuscript Source Unsolicited Manuscript
All Author List Michelle L Boland, Denise Oró, Kirstine S Tølbøl, Sebastian T Thrane, Jens Christian Nielsen, Taylor S Cohen, David E Tabor, Fiona Fernandes, Andrey Tovchigrechko, Sanne S Veidal, Paul Warrener, Bret R Sellman, Jacob Jelsing, Michael Feigh, Niels Vrang, James L Trevaskis and Henrik H Hansen
Author(s) ORCID Number
Michelle L Boland http://orcid.org/0000-0002-9920-2088
Denise Oró http://orcid.org/0000-0001-5255-3692
Kirstine S Tølbøl http://orcid.org/0000-0001-6817-7441
Sebastian T Thrane http://orcid.org/0000-0002-4802-8665
Jens Christian Nielsen http://orcid.org/0000-0002-6522-9987
Taylor S Cohen http://orcid.org/0000-0001-9368-0903
David E Tabor http://orcid.org/0000-0002-8016-9281
Fiona Fernandes http://orcid.org/0000-0003-3117-5543
Andrey Tovchigrechko http://orcid.org/0000-0002-0959-4429
Sanne S Veidal http://orcid.org/0000-0003-1240-2034
Paul Warrener http://orcid.org/0000-0001-8597-7029
Bret R Sellman http://orcid.org/0000-0002-1172-8799
Jacob Jelsing http://orcid.org/0000-0002-4583-1022
Michael Feigh http://orcid.org/0000-0001-5274-8799
Niels Vrang http://orcid.org/0000-0002-7203-9532
James L Trevaskis http://orcid.org/0000-0002-5356 -6118
Henrik H Hansen http://orcid.org/0000-0002-3732-0281
Funding Agency and Grant Number
Funding Agency Grant Number
Innovation Fund Denmark 5016-00168B
Corresponding author Henrik H Hansen, PhD, Senior Scientist, Pharmacology, Gubra, Hørsholm Kongevej 11B, Hoersholm DK-2970, Denmark. hbh@gubra.dk
Keywords Non-alcoholic steatohepatitis; High-fat diet; Mouse model; Histopathology; Fibrosis; Liver biopsy
Core Tip The trans-fat containing amylin liver non-alcoholic steatohepatitis (NASH) (AMLN) diet has been extensively validated in mice for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH. A recent ban on trans-fats as food additive prompted the development of a new diet with similar disease-inducing properties as the AMLN diet. Here, we introduce a trans-fat-free diet high in palm oil (Gubra amylin NASH, GAN diet) that promotes a highly similar phenotype of biopsy-confirmed fibrotic NASH in both ob/ob and C57BL/6J mice, highlighting the suitability of GAN diet-induced obese mouse models of biopsy-confirmed NASH for the characterization of novel drug therapies for NASH.
Publish Date 2019-09-07 04:43
Citation Boland ML, Oró D, Tølbøl KS, Thrane ST, Nielsen JC, Cohen TS, Tabor DE, Fernandes F, Tovchigrechko A, Veidal SS, Warrener P, Sellman BR, Jelsing J, Feigh M, Vrang N, Trevaskis JL, Hansen HH. Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source. World J Gastroenterol 2019; 25(33): 4904-4920
Url https://www.wjgnet.com/1007-9327/full/v25/i33/4904.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i33.4904
Full Article (PDF) WJG-25-4904.pdf
Full Article (Word) WJG-25-4904.docx
Manuscript File 48566-Review.docx
Answering Reviewers 48566-Answering reviewers.pdf
Audio Core Tip 48566-Audio core tip.m4a
Biostatistics Review Certificate 48566-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 48566-Conflict-of-interest statement.pdf
Copyright License Agreement 48566-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 48566-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 48566-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 48566-Institutional review board statement.pdf
Supplementary Material 48566-Supplementary material.pdf
Peer-review Report 48566-Peer-review(s).pdf
Scientific Misconduct Check 48566-Scientific misconduct check.pdf
Scientific Editor Work List 48566-Scientific editor work list.pdf