Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	48680
Country	Japan

Received	2019-04-28 01:54
Peer-Review Started	2019-05-09 02:21
To Make the First Decision	2019-06-13 02:13
Return for Revision	2019-06-17 03:32
Revised	2019-06-30 23:56
Second Decision	2019-08-21 03:53
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-08-21 18:54
Articles in Press	2019-08-21 18:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-05 03:54
Publish the Manuscript Online	2019-09-09 01:54

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Immune checkpoint inhibitor-induced diarrhea/colitis: Endoscopic and pathologic findings
Manuscript Source	Invited Manuscript
All Author List	Tsutomu Nishida, Hideki Iijima and Shiro Adachi
ORCID	Author(s) ORCID Number Tsutomu Nishida http://orcid.org/0000-0003-4037-9003 Hideki Iijima http://orcid.org/0000-0002-5423-3059 Shiro Adachi http://orcid.org/0000-0001-6159-1682
Funding Agency and Grant Number
Corresponding Author	Tsutomu Nishida, MD, PhD, Doctor, Doctor, Department of Gastroenterology, Toyonaka Municipal Hospital, 4-14-1 Shibahara, Toyonaka, Osaka 560-8565, Japan. tnishida.gastro@gmail.com
Key Words	Immune checkpoint inhibitor; Colitis; Diarrhea; Endoscopic; Pathologic;
Core Tip	Immune checkpoint inhibitor (ICPI)-induced colitis/diarrhea is frequent and recognized not only by oncologists but also by gastroenterologists or endoscopists. The endoscopic findings resemble those of inflammatory bowel disease to a certain extent, particularly ulcerative colitis, but are not identical. The pathological findings of ICPI-induced colitis may vary among drug classes. The findings show acute or chronic phases but may depend on the diagnostic timing or treatment intervention. Colonoscopy with biopsy is necessary to confirm ICPI-induced colitis, and early evaluation may avoid exacerbating or prolonging colitis due to treatment resistance.
Publish Date	2019-09-09 01:54
Citation	Nishida T, Iijima H, Adachi S. Immune checkpoint inhibitor-induced diarrhea/colitis: Endoscopic and pathologic findings. World J Gastrointest Pathophysiol 2019; 10(2): 17-28
URL	https://www.wjgnet.com/2150-5330/full/v10/i2/17.htm
DOI	https://dx.doi.org/10.4291/wjgp.v10.i2.17

Full Article (PDF)	WJGP-10-17.pdf
Manuscript File	48680-Review.docx
Answering Reviewers	48680-Answering reviewers.pdf
Audio Core Tip	48680-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	48680-Conflict-of-interest statement.pdf
Copyright License Agreement	48680-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	48680-Language certificate.pdf
Peer-review Report	48680-Peer-review(s).pdf
Scientific Misconduct Check	48680-Scientific misconduct check.pdf
Scientific Editor Work List	48680-Scientific editor work list.pdf
CrossCheck Report	48680-CrossCheck report.pdf