Publication Name	World Journal of Medical Genetics
Manuscript ID	4890
Country	China

Received	2013-07-31 10:06
Peer-Review Started	2013-07-31 17:34
To Make the First Decision	2013-09-09 14:27
Return for Revision	2013-09-12 10:33
Revised	2013-09-29 18:08
Second Decision	2013-11-15 18:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-16 00:50
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-09 15:20
Typeset the Manuscript	2014-05-27 18:56
Publish the Manuscript Online	2014-05-28 15:12

ISSN	2220-3184 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Autobiography
Article Title	Earlier onset and multiple primaries in familial as opposed to sporadic esophageal cancer
Manuscript Source	Invited Manuscript
All Author List	Xiao-Duo Wen, Deng-Gui Wen, Yi Yang, Bao-En Shan and Shi-Jie Wang
Funding Agency and Grant Number
Corresponding Author	Dr. Shi-Jie Wang, MD, Cancer Center, 4th Hospital of Hebei Medical University, Jiankanglu 12, Shijiazhuang 050011, Hebei Province, China. wshjw136@aliyun.com
Key Words	Esophageal squamous cell carcinoma; Familial cancer; Sporadic cancer; Age at onset; Synchronous primary carcinoma
Core Tip	Patients with esophageal squamous cell carcinoma (ESCC) and a positive family history had a significantly younger onset age and more multiple primary cancers than those without a positive family history (51.83 ± 8.39 vs 53.49 ± 8.23 years old, P = 0.000; 5.50% vs 1.70%, P = 0.000). Both of these differences were evident in sub-group analyses, however, no correlations were observed. While age at onset differed significantly by family history in males, smokers, and drinkers, the difference in multiple primary cancers by family history was significant in nonsmoking, nondrinking, and younger onset patients. These results suggest a genetic component in ESCC. Furthermore, a younger onset age may be due to the interaction of genetic predisposition and environmental hazards, and multiple primary cancers may only be due to genetic predisposition.
Publish Date	2014-05-28 15:12
Citation	Wen XD, Wen DG, Yang Y, Shan BE, Wang SJ. Earlier onset and multiple primaries in familial as opposed to sporadic esophageal cancer. World J Med Genet 2014; 4(2): 39-45
URL	http://www.wjgnet.com/2220-3184/full/v4/i2/39.htm
DOI	http://dx.doi.org/10.5496/wjmg.v4.i2.39

Full Article (PDF)	WJMG-4-39.pdf
Full Article (Word)	WJMG-4-39.doc
Manuscript File	4890-Review.doc
Answering Reviewers	4890-Answering Reviewers.pdf
Biostatistics Review Certificate	Biostatistician_Review_Report_20130730164241.docx
Copyright License Agreement	4890-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20130730164108.docx
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20130730164604.docx
Peer-review Report	4890-Peer Review(s).pdf
Scientific Editor Work List	4890-Scientific editor work list.doc