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Articles Published Processes
8/16/2019 12:41:28 AM | Browse: 824 | Download: 1689
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Received |
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2019-05-16 02:19 |
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Peer-Review Started |
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2019-05-21 00:58 |
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To Make the First Decision |
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2019-07-22 05:24 |
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Return for Revision |
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2019-07-22 05:31 |
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Revised |
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2019-07-31 03:26 |
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Second Decision |
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2019-08-03 04:22 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-08-03 04:23 |
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Articles in Press |
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2019-08-03 04:23 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-08-15 05:58 |
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Publish the Manuscript Online |
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2019-08-16 00:41 |
| ISSN |
1948-5204 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
shRNA-interfering LSD1 inhibits proliferation and invasion of gastric cancer cells via VEGF-C/PI3K/AKT signaling pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Ming Pan, Wei-Ya Lang, Li-Jie Yao, Yan Wang and Xiao-Ling Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Doctoral Special Research Fund of Qiqihar Medical College |
QY2016B-06 |
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| Corresponding Author |
Xiao-Ling Li, PhD, Associate Professor, Department of Anatomy, Qiqihar Medical University, No. 333 Bukui North Street, Jianhua District, Qiqihar 161006, Heilongjiang Province, China. lixiaoling0420@126.com |
| Key Words |
Gastric cancer; Lysine specific histone demethylase 1; Cell proliferation; Cell invasion; VEGF-C/PI3K/AKT signaling pathway; |
| Core Tip |
The abnormal regulation of Lysine Specific Demethylase 1 (LSD1) is closely related to the occurrence and development of various cancers, such as gastric cancer. LSD1 is highly expressed in gastric cancer tissues, and the change in LSD1 expression level plays an important role in the proliferation and metastasis of gastric cancer cells. The VEGF-C/PI3K/AKT signaling pathway plays an important role in lymphangiogenesis and metastasis of gastric cancer. Therefore, this study investigated downregulation of LSD1 expression in order to observe the changes in gastric cancer cell proliferation and invasion, and further explored the role of the VEGF-C/PI3K/AKT signaling pathway. This study explores the role and mechanism of LSD1 in inhibiting gastric cancer cell metastasis from the perspective of epigenetics, providing a basis for early clinical diagnosis of gastric cancer metastasis. |
| Publish Date |
2019-08-16 00:41 |
| Citation |
Pan HM, Lang WY, Yao LJ, Wang Y, Li XL. shRNA-interfering LSD1 inhibits proliferation and invasion of gastric cancer cells via VEGF-C/PI3K/AKT signaling pathway. World J Gastrointest Oncol 2019; 11(8): 622-633 |
| URL |
https://www.wjgnet.com/1948-5204/full/v11/i8/622.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v11.i8.622 |
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