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Articles Published Processes
10/21/2019 9:37:00 AM | Browse: 575 | Download: 1299
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Received |
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2019-05-20 00:27 |
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Peer-Review Started |
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2019-05-20 08:51 |
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To Make the First Decision |
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2019-07-22 03:43 |
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Return for Revision |
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2019-07-24 02:11 |
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Revised |
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2019-08-08 08:10 |
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Second Decision |
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2019-09-12 09:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-09-13 04:19 |
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Articles in Press |
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2019-09-13 04:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-09-29 23:14 |
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Typeset the Manuscript |
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2019-10-18 03:02 |
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Publish the Manuscript Online |
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2019-10-21 09:37 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Infectious Diseases |
| Manuscript Type |
Basic Study |
| Article Title |
Construction of replication-competent hepatitis B virus vector carrying secreted luciferase transgene and new hepatitis B virus replication and expression cell lines
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jie Ruan, Cai-Yan Ping, Shuo Sun, Xin Cheng, Peng-Yu Han, Yin-Ge Zhang and Dian-Xing Sun |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China |
81672041 |
| the National Major Science and Technology Special Project for Infectious Diseases of China |
2012ZX10004503-012 |
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| Corresponding Author |
Dian-Xing Sun, PhD, Doctor, Doctor, Professor, The Liver Disease Center of Chinese People’s Liberation Army, the 980th Hospital of Chinese People’s Liberation Army Joint Logistics Support Force, Shijiazhuang, zhongshanxi street, Shijiazhuang 050082, Hebei Province, China. sundianxing@hotmail.com |
| Key Words |
Hepatitis B virus; Replication-competent hepatitis B virus vector; Secreted luciferase gene; Hepatitis B virus cell line; ; |
| Core Tip |
In this research, we constructed a replication-competent hepatitis B virus (HBV) vector carrying a secreted luciferase transgene and established HBV replication and expression cell lines that could stably secrete secretory NanolucTM Luciferase recombinant viral particles. This vector is a convenient and quantifiable tool for monitoring HBV replication, transcription and expression. It was safe to assume that this new HBV replication system ought to be used in HBV molecular biology research, such as for discovering inhibitors that affect infection, entry, transcription, translation, reverse transcription, and replication. |
| Publish Date |
2019-10-21 09:37 |
| Citation |
Ruan J, Ping CY, Sun S, Cheng X, Han PY, Zhang YG and Sun DX. Construction of replication-competent hepatitis B virus vector carrying secreted luciferase transgene and new hepatitis B virus replication and expression cell lines. World J Gastroenterol 2019; 25(39): 5961-5972 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i39/5961.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i39.5961 |
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