Publication Name	World Journal of Hepatology
Manuscript ID	4929
Country	Italy

Received	2013-08-02 08:06
Peer-Review Started	2013-08-03 22:49
To Make the First Decision	2013-08-21 18:51
Return for Revision	2013-08-28 11:07
Revised
Second Decision	2013-11-15 19:07
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-16 01:48
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-25 08:43
Publish the Manuscript Online	2014-01-11 22:00

ISSN	1948-5182 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Physiology
Manuscript Type	Minireviews
Article Title	New compounds able to control hepatic cholesterol metabolism: Is it possible to avoid statin treatment in aged people?
Manuscript Source	Invited Manuscript
All Author List	Laura Trapani, Marco Segatto and Valentina Pallottini
Funding Agency and Grant Number
Corresponding Author	Valentina Pallottini, Assistant Professor of Physiology, Department of Science, Section Biomedical Science and Technologies, University Roma Tre, Viale Marconi 446, 00146 Rome, Italy. pallottini@uniroma3.it
Key Words	Neurotrophins; Metabotrophins; Adipose tissue; Adipokines; Disease; Therapy
Core Tip	The strategies used to reduce plasma cholesterol levels in elderly people are mainly addressed to the inhibition of the rate limiting enzyme of cholesterol biosynthetic pathway, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR), in order to increase low density lipoprotein (LDL) receptor membrane exposure and LDL clearance from the circulation. Indeed current therapies are mostly based on the prescription of statins (HMGR inhibitors) that are pretty effective but that exert side effects. More attention should be given to potential drug interactions, potential age-related changes in drug pharmacokinetics, adverse effects such as myopathy and competing risks when statins are prescribed to elderly. Thus, new therapeutic agents should be taken into account.
Publish Date	2014-01-11 22:00
Citation	Trapani L, Segatto M, Pallottini V. New compounds able to control hepatic cholesterol metabolism: Is it possible to avoid statin treatment in aged people? World J Hepatol 2013; 5(12): 676-684
URL	http://www.wjgnet.com/1948-5182/full/v5/i12/676.htm
DOI	http://dx.doi.org/10.4254/wjh.v5.i12.676

Full Article (PDF)	WJH-5-676.pdf
Full Article (Word)	WJH-5-676.doc
Manuscript File	4929-Review.docx
Answering Reviewers	4929-Answering reviewers.pdf
Copyright License Agreement	4929-Copyright assignment.pdf
Peer-review Report	4929-Peer reviewer(s).pdf
Scientific Editor Work List	4929-Scientific editor work list.doc