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Articles Published Processes
9/12/2019 8:50:34 AM | Browse: 900 | Download: 1410
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Received |
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2019-05-28 01:17 |
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Peer-Review Started |
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2019-05-28 06:10 |
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To Make the First Decision |
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2019-07-22 03:33 |
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Return for Revision |
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2019-07-23 02:24 |
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Revised |
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2019-07-26 10:54 |
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Second Decision |
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2019-08-02 10:24 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-08-07 09:31 |
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Articles in Press |
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2019-08-07 09:31 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-09-11 08:25 |
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Publish the Manuscript Online |
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2019-09-12 08:50 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Optimizing proton pump inhibitors in Helicobacter pylori treatment: Old and new tricks to improve effectiveness
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Enzo Ierardi, Giuseppe Losurdo, Rosa Federica La Fortezza, Mariabeatrice Principi, Michele Barone and Alfredo Di Leo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Enzo Ierardi, MD, Academic Fellow, Associate Professor, Doctor, Doctor, Section of Gastroenterology, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, Bari 70124, Italy. e.ierardi@virgilio.it |
| Key Words |
Helicobacter pylori; Proton pump inhibitors; Eradication; Cytochrome P450; Optimization; |
| Core Tip |
The most adequate acid suppression by proton pump inhibitors (PPIs) is fundamental to optimize antibiotic therapies for Helicobacter pylori eradication. Herein, we summarize data from literature in order to ascertain the most effective strategies in this topic. Increasing PPI dose showed a real benefit on eradication rate even in the absence of dedicated trials. Second-generation PPIs, as demonstrated in some meta-analyses, may be more effective than old PPI molecules. Finally, vonoprazan, a novel molecule, has shown promising results but, currently, data come from Asian countries, therefore its strong power needs to be confirmed outside this geographic area. |
| Publish Date |
2019-09-12 08:50 |
| Citation |
Ierardi E, Losurdo G, La Fortezza RF, Principi M, Barone M, Di Leo A. Optimizing proton pump inhibitors in Helicobacter pylori treatment: Old and new tricks to improve effectiveness. World J Gastroenterol 2019; 25(34): 5097-5104 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i34/5097.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i34.5097 |
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