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Articles Published Processes
10/21/2019 9:37:00 AM | Browse: 870 | Download: 1813
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Received |
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2019-06-04 00:50 |
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Peer-Review Started |
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2019-06-04 06:17 |
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To Make the First Decision |
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2019-07-22 02:21 |
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Return for Revision |
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2019-07-22 07:18 |
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Revised |
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2019-08-15 03:32 |
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Second Decision |
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2019-09-20 09:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-09-28 04:49 |
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Articles in Press |
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2019-09-28 04:49 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-10-18 05:04 |
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Publish the Manuscript Online |
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2019-10-21 09:37 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Gut-liver axis signaling in portal hypertension
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Benedikt Simbrunner, Mattias Mandorfer, Michael Trauner and Thomas Reiberger |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Thomas Reiberger, MD, Associate Professor, Doctor, Doctor, Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Spitalgasse 23, Vienna A-1090, Austria. thomas.reiberger@meduniwien.ac.at |
| Key Words |
Cirrhosis; Portal hypertension; Gut-liver axis; Bacterial translocation; Intestinal barrier; Farnesoid X receptor |
| Core Tip |
In advanced chronic liver disease, portal hypertension (PHT) results from increased intrahepatic resistance and leads to splanchnic vasodilation and neovascularization in the intestines. Gut dysbiosis, increased intestinal permeability, translocation of bacteria and pathogen-associated molecular patterns can further promote liver disease progression, often mediated via immune system activation and a subsequent induction of a proinflammatory state. The close relationship between gut and liver and their bidirectional interaction has been termed gut-liver axis. This review aims to connect the impact of PHT on the gut-liver axis by providing both insight into pathophysiology and clinical observations, as well as therapeutic strategies. |
| Publish Date |
2019-10-21 09:37 |
| Citation |
Simbrunner B, Mandorfer M, Trauner M, Reiberger T. Gut-liver axis signaling in portal hypertension. World J Gastroenterol 2019; 25(39): 5897-5917 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i39/5897.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i39.5897 |
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