Publication Name	World Journal of Clinical Cases
Manuscript ID	49601
Country	Germany

Received	2019-06-04 00:46
Peer-Review Started	2019-06-06 10:40
To Make the First Decision	2019-08-02 03:20
Return for Revision	2019-08-02 09:16
Revised	2019-10-09 09:26
Second Decision	2019-10-11 00:42
Accepted by Journal Editor-in-Chief	2019-10-11 01:24
Accepted by Executive Editor-in-Chief	2019-10-15 05:18
Articles in Press	2019-10-15 05:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-11-21 12:01
Publish the Manuscript Online	2019-11-26 07:21

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Microbial transglutaminase should be considered as an environmental inducer of celiac disease
Manuscript Source	Unsolicited Manuscript
All Author List	Aaron Lerner and Torsten Matthias
ORCID	Author(s) ORCID Number Aaron Lerner http://orcid.org/0000-0002-6779-4090 Torsten Matthias http://orcid.org/0000000267794090
Funding Agency and Grant Number
Corresponding Author	Aaron Lerner, MD, Academic Research, Associate Professor, Aesku.KIPP Institute, Mikroforum Ring 2, Wesdelsheim 55234, Germany. aaronlerner1948@gmail.com
Key Words	Microbial transglutaminase; Transglutaminase 2; Celiac disease; Processed food; Food additive; Food industry
Core Tip	Recently, various food additives were suspected to trigger autoimmunity, including celiac disease (CD). Microbial transglutaminase (mTG), a heavily used one that imitates functionally the autoantigen of CD is a prime environmental candidate to induce the disease. The enzyme increases gliadin uptake, is transported in a trans-epithelial way, has anti- phagocytic activity, enhances intestinal permeability and creates luminal resistant isopeptide bonds. Its gliadin cross-linked complexes are immunogenic and reflect the degree of intestinal injury in CD patients. The present letter updates and explains why the protein linker, mTG, is beneficial to food industries but a caveat to public health.
Publish Date	2019-11-26 07:21
Citation	Lerner A, Matthias T. Microbial transglutaminase should be considered as an environmental inducer of celiac disease. World J Clin Cases 2019; 7(22): 3912-3914
URL	https://www.wjgnet.com/2307-8960/full/v7/i22/3912.htm
DOI	https://dx.doi.org/10.12998/wjcc.v7.i22.3912

Full Article (PDF)	WJCC-7-3912.pdf
Full Article (Word)	WJCC-7-3912.docx
Manuscript File	49601-Review.docx
Answering Reviewers	49601-Answering reviewers.pdf
Audio Core Tip	49601-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	49601-Conflict-of-interest statement.pdf
Copyright License Agreement	49601-Copyright license agreement.pdf
Peer-review Report	49601-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	49601-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	49601-Scientific misconduct check.pdf
Scientific Editor Work List	49601-Scientific editor work list.pdf
CrossCheck Report	49601-CrossCheck report.pdf