| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Shuo Chao, Sen-Lin Zhao, Si-Wen Ou-yang, Yong-Bing Qian, Ai-Qun Liu, Hua-Mei Tang, Lin Zhong, Zhi-Hai Peng, Jun-Ming Xu and Hong-Cheng Sun |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Funds of Chinese National Natural Science Foundation Project |
81672846 |
| the Funds of Chinese National Natural Science Foundation Project |
81670595 |
|
| Corresponding Author |
Hong-Cheng Sun, MD, PhD, Associate Chief Physician, Associate Professor, Director, Surgeon, Surgical Oncologist, Department of General Surgery, Shanghai Organ Transplantation Medical Center, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, 100 Haining Road, Shanghai 200080, Shanghai, China. sunhongchengmd@163.com |
| Key Words |
Liver transplantation; Liver cancer; Infection; Survival; Tumor recurrence; |
| Core Tip |
Post-transplant infection (PTI) is routinely deemed as a harmful event for liver transplant recipients from a short-term perspective. Nevertheless, the present study demonstrated that PTI prolonged overall and recurrence-free survival of the patients with hepatocellular carcinoma (HCC) at high risk of post-transplant death and tumor recurrence, which may be attributed to the persistent tumor suppressive effect of PTI on HCC recurrence after orthotopic liver transplantation (OLT). Further prospective multicenter investigations and experimental studies regarding the mechanism by which PTI inhibited HCC progression may contribute to future successful prophylaxis of HCC recurrence after OLT. |
| Publish Date |
2019-09-30 02:14 |
| Citation |
Chao JS, Zhao SL, Ou-yang SW, Qian YB, Liu AQ, Tang HM, Zhong L, Peng ZH, Xu JM, Sun HC. Post-transplant infection improves outcome of hepatocellular carcinoma patients after orthotopic liver transplantation. World J Gastroenterol 2019; 25(37): 5630-5640 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i37/5630.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i37.5630 |
