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Articles Published Processes
12/12/2019 12:15:56 AM | Browse: 770 | Download: 1038
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Received |
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2019-06-11 00:41 |
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Peer-Review Started |
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2019-06-11 08:16 |
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To Make the First Decision |
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2019-07-31 06:07 |
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Return for Revision |
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2019-08-07 01:57 |
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Revised |
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2019-08-27 23:07 |
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Second Decision |
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2019-08-30 11:52 |
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Accepted by Journal Editor-in-Chief |
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2019-09-01 05:24 |
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Accepted by Company Editor-in-Chief |
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2019-09-16 00:55 |
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Articles in Press |
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2019-09-16 00:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-09-21 02:52 |
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Typeset the Manuscript |
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2019-12-02 02:01 |
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Publish the Manuscript Online |
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2019-12-12 00:15 |
| ISSN |
2218-5836 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Effect of clopidogrel in bone healing-experimental study in rabbits
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Theodoros Lillis, Alexander Veis, Nikolaos Sakellaridis, Anastasios Tsirlis and Zoe H Dailiana |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Zoe H Dailiana, MD, PhD, Professor, Surgeon, Department of Orthopaedic Surgery, Faculty of Medicine, University of Thessalia, 3 Panepistimiou St., Larissa 41500, Greece. dailiana@med.uth.gr |
| Key Words |
Clopidogrel; Bone healing; Purinergic signaling; Calvarial defect; Rabbit; |
| Core Tip |
To our knowledge, the present study is the first to evaluate the effect of clopidogrel treatment on bone healing. Clopidogrel is an antithrombotic drug that inhibits platelet aggregation through inhibition of the P2Y12 purinergic receptor on their surface. The P2Y12 is also expressed in osteoblasts and osteoclasts, and previous studies have raised concerns about clopidogrel’s possible effect on bone metabolism. We report our results on the effect of clopidogrel on bone healing using the rabbit calvarial defect model. Our results indicate that clopidogrel treatment not only does not negatively affect bone healing, but rather promotes it. |
| Publish Date |
2019-12-12 00:15 |
| Citation |
Lillis T, Veis A, Sakellaridis N, Tsirlis A, Dailiana Z. Effect of clopidogrel in bone healing-experimental study in rabbits. World J Orthop 2019; 10(12): 434-445 |
| URL |
https://www.wjgnet.com/2218-5836/full/v10/i12/434.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v10.i12.434 |
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