| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Hepatitis C virus clearance and less liver damage in patients with high cholesterol, low-density lipoprotein cholesterol and APOE ε4 allele
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Karina Gonzalez-Aldaco, Sonia Roman, Rafael Torres-Valadez, Claudia Ojeda-Granados, Luis Alberto Torres-Reyes and Arturo Panduro |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Programa para el Desarrollo Profesional Docente |
UDG-PTC-1422 |
| Consejo Nacional de Ciencia y Tecnología |
2017-01-5254 |
|
| Corresponding Author |
Arturo Panduro, MD, PhD, Professor, Research Scientist, Senior Scientist, Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara Fray Antonio Alcalde/University of Guadalajara, Hospital # 278
Col. El Retiro,, Guadalajara 44280, Jalisco, Mexico. biomomed@cencar.udg.mx |
| Key Words |
Liver damage; Body mass index; Spontaneous hepatitis C virus clearance; Low-density lipoprotein; Cholesterol; |
| Core Tip |
Cholesterol is a metabolic regulator of the hepatitis C virus (HCV) life cycle. Genetic polymorphisms in the APOE gene can regulate cholesterol and modify the outcome of the HCV infection. Our findings suggest that APOE ε4 allele and low-density lipoprotein cholesterol (LDL-c) confer a protective effect in the course of the HCV infection in the context of high body mass index (BMI). Levels of LDL-c, BMI, and ALT may estimate the risk of chronicity in HCV-infected patients. An individualized therapy accounting the host´s genetic, environmental, and metabolic factors could aid in the clinical management of HCV infection, especially in populations with a high prevalence of overweight and obesity. |
| Publish Date |
2019-10-14 10:47 |
| Citation |
Gonzalez-Aldaco K, Roman S, Torres-Valadez R, Ojeda-Granados C, Torres-Reyes LA, Panduro A. Hepatitis C virus clearance and less liver damage in patients with high cholesterol, low-density lipoprotein cholesterol and APOE ε4 allele. World J Gastroenterol 2019; 25(38): 5826-5837 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i38/5826.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i38.5826 |
