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Articles Published Processes
11/21/2019 10:02:33 AM | Browse: 768 | Download: 1406
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Received |
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2019-06-21 01:04 |
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Peer-Review Started |
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2019-06-26 14:36 |
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To Make the First Decision |
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2019-08-06 01:17 |
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Return for Revision |
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2019-08-06 06:39 |
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Revised |
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2019-09-17 20:29 |
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Second Decision |
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2019-10-25 06:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-10-29 00:09 |
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Articles in Press |
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2019-10-29 00:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-11-08 11:53 |
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Publish the Manuscript Online |
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2019-11-21 10:02 |
| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Minocycline fails to improve neurologic and histologic outcome after ventricular fibrillation cardiac arrest in rats
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Andreas Janata, Ingrid AM Magnet, Kristin L Schreiber, Caleb D Wilson, Jason P Stezoski, Keri Janesko-Feldman, Patrick M Kochanek and Tomas Drabek |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Laerdal Foundation for Acute Medicine |
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| Erwin Schroedinger Stipend |
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| Society of Cardiovascular Anesthesiologists |
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| International Anesthesia Research Society |
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| Corresponding Author |
Tomas Drabek, MD, PhD, Associate Professor, Research Scientist, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, 4401 Penn Avenue, Pittsburgh, PA 15224, United States. drabekt@anes.upmc.edu |
| Key Words |
Heart arrest/pathology; Cardiopulmonary resuscitation; Survival rate; Neurons/drug effects; Microglia/drug effects; Minocycline/pharmacology |
| Core Tip |
Prolonged cardiac arrest (CA) produces extensive neuronal death and neuroinflammation resulting in neuro-cognitive disabilities via ischemia-reperfusion injury. Minocycline was shown neuroprotective in some brain ischemia models, in part by blunting the microglial response or by a direct effect on neurons. In our established experimental CA model in adult rats, minocycline did not improve survival and failed to confer substantial benefits on survival, neurobehavioral outcome, neuronal loss or microglial proliferation across multiple brain regions. |
| Publish Date |
2019-11-21 10:02 |
| Citation |
Janata A, Magnet IAM, Schreiber KL, Wilson CD, Stezoski JP, Janesko-Feldman K, Kochanek PM, Drabek T. Minocycline fails to improve neurologic and histologic outcome after ventricular fibrillation cardiac arrest in rats. World J Crit Care Med 2019; 8(7): 106-119 |
| URL |
https://www.wjgnet.com/2220-3141/full/v8/i7/106.htm |
| DOI |
https://dx.doi.org/10.5492/wjccm.v8.i7.106 |
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