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Articles Published Processes
11/4/2019 2:30:59 AM | Browse: 846 | Download: 1561
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Received |
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2019-07-18 22:52 |
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Peer-Review Started |
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2019-07-21 10:30 |
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To Make the First Decision |
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2019-09-02 01:38 |
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Return for Revision |
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2019-09-06 07:50 |
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Revised |
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2019-09-11 23:24 |
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Second Decision |
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2019-09-29 06:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-10-07 19:18 |
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Articles in Press |
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2019-10-07 19:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-10-15 21:45 |
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Typeset the Manuscript |
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2019-11-01 06:07 |
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Publish the Manuscript Online |
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2019-11-04 02:30 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Observational Study |
| Article Title |
Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Natalia Gomez-Lopera, Juan M Alfaro, Suzanne M Leal and Nicolas Pineda-Trujillo |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Colciencias |
111556933366 |
| CODI- Universidad de Antioquia |
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| Colciencias. NG-L |
727cfrom 2015 |
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| Corresponding Author |
Nicolas Pineda-Trujillo, MSc, PhD, Academic Research, Research Scientist, Senior Scientist, Grupo Mapeo Genetico, Departamento de Pediatría, Facultad de Medicina, Universidad de Antioquia, Carrera 51D No. 62-21, Medellín 050010470, Colombia. nicolas.pineda@udea.edu.co |
| Key Words |
Type 1 diabetes; Genetic admixture; Native American; Idiopathic; Colombia; |
| Core Tip |
We have tested the effect of genetic admixture in a set of Colombian patients with Type 1 Diabetes (T1D). It is shown that although globally no differences between T1D and Colombians Living in Medellin subjects arosed, there appear ancestry differences when looking at specific T1D loci/genes (e.g., genes EFR3B, IFIH1, IL7R and NRP1). Also, when comparing patients ancestry according to the presence/absence of T1D related auto-antibodies or age at onset of the disease, differences were also observed. The most striking differences in ancestry occurred outside the HLA region, which is considered the master risk locus in T1D and for autoimmune diseases overall. This is itself a striking observation. |
| Publish Date |
2019-11-04 02:30 |
| Citation |
Gomez-Lopera N, Alfaro JM, Leal SM, Pineda-Trujillo N. Type 1 diabetes loci display a variety of native American and African ancestries in diseased individuals from Northwest Colombia. World J Diabetes 2019; 10(11): 534-545 |
| URL |
https://www.wjgnet.com/1948-9358/full/v10/i11/534.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v10.i11.534 |
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