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Articles Published Processes
10/28/2019 11:23:12 AM | Browse: 944 | Download: 1865
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Received |
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2019-07-25 09:50 |
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Peer-Review Started |
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2019-07-24 13:49 |
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To Make the First Decision |
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2019-08-19 00:48 |
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Return for Revision |
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2019-08-23 02:49 |
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Revised |
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2019-09-17 11:06 |
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Second Decision |
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2019-09-26 10:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-09-28 04:45 |
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Articles in Press |
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2019-09-28 04:45 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-10-25 09:26 |
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Publish the Manuscript Online |
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2019-10-28 11:23 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jae Ryang Chu, Saem-Yi Kang, Sung-Eun Kim, Sol-Ji Lee, Young-Chul Lee and Mi-Kyung Sung |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Unigen, Inc. |
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| Mid-Career Research Program of the National Research Foundation of Korea |
No.2015R1A2A2A01004607 |
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| Corresponding Author |
Mi-Kyung Sung, PhD, Full Professor, Food and Nutrtion, Sookmyung Women's University, 100 Cheongpa-ro 47-gil, Yongsan-gu, Seoul 04310, South Korea. mksung@sookmyung.ac.kr |
| Key Words |
Prebiotics; Constipation; Gut microbiota; Endotoxemia; Short-chain fatty acids; |
| Core Tip |
This randomized clinical study assessed the efficacy of the prebiotic UG1601 in suppressing constipation-related adverse events in subjects with mild constipation. Forty adults with a stool frequency of less than thrice a week were received either prebiotics or placebo supplements for 4 wk. Serum endotoxemia markers were decreased and Roseburia hominis, a major butyrate producer was increased after prebiotic usage. The abundance of Firmicutes was deceased in the responders within the prebiotic group representing the inverse associations with several fecal short-chain fatty acids. Thus, alterations in gut microbiota composition following prebiotic UG1601 supplementation might contribute to alleviation of symptom scores and endotoxemia. |
| Publish Date |
2019-10-28 11:23 |
| Citation |
Chu JR, Kang SY, Kim SE, Lee SJ, Lee YC, Sung MK. Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study. World J Gastroenterol 2019; 25(40): 6129-6144 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i40/6129.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i40.6129 |
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