Publication Name	World Journal of Diabetes
Manuscript ID	50677
Country	United States

Received	2019-08-03 00:16
Peer-Review Started	2019-08-03 00:17
To Make the First Decision	2019-09-29 03:06
Return for Revision	2019-10-14 02:03
Revised	2019-11-07 19:31
Second Decision	2019-11-26 08:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-11-26 22:20
Articles in Press	2019-11-26 22:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-12-12 06:26
Publish the Manuscript Online	2019-12-17 07:13

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author (s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus
Manuscript Source	Unsolicited Manuscript
All Author List	Kyumin Shim, Rayhana Begum, Catherine Yang and Hongbin Wang
ORCID	Author(s) ORCID Number Kyumin Shim http://orcid.org/0000-0001-6893-3315 Rayhana Begum http://orcid.org/0000-0002-3246-3099 Catherine Yang http://orcid.org/0000-0002-0764-4373 Hongbin Wang http://orcid.org/0000-0002-4490-0006
Funding Agency and Grant Number
Corresponding Author	Hongbin Wang, BPharm, MSc, PhD, Assistant Professor, Department of Biomedical and Pharmaceutical Sciences, California Northstate University College of Pharmacy, 9700 W Taron Dr., Elk Grove, CA 95757, United States. hongbin.wang@cnsu.edu
Key Words	Inflammation; Complement activation; Metabolic disorders; Obesity; Insulin resistance; Type 2 diabetic mellitus
Core Tip	Inflammatory reaction is involved in cardiometabolic diseases such as obesity, insulin resistance, and diabetes. The complement system, a key component of innate immunity, was viewed as the first line of defense against microbial. Recent research has come to appreciate that the complement system is involved in such diverse processes as clearance of the immune complexes, complementing immune functions, tissue regeneration, and metabolism. The review is to update the role of the activation of complement system and the progression of metabolic disorders. We provided a paradigm that targeting complement therapeutics could be one of possible routes to slow down diabetic complications.
Publish Date	2019-12-17 07:13
Citation	Shim K, Begum R, Yang C, Wang H. Complement activation in obesity, insulin resistance, and type 2 diabetes mellitus. World J Diabetes 2020; 11(1): 1-12
URL	https://www.wjgnet.com/1948-9358/full/v11/i1/1.htm
DOI	https://dx.doi.org/10.4239/wjd.v11.i1.1

Full Article (PDF)	WJD-11-1.pdf
Full Article (Word)	WJD-11-1.docx
Manuscript File	50677-Review.docx
Answering Reviewers	50677-Answering reviewers.pdf
Audio Core Tip	50677-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	50677-Conflict-of-interest statement.pdf
Copyright License Agreement	50677-Copyright license agreement.pdf
Peer-review Report	50677-Peer-review(s).pdf
Scientific Misconduct Check	50677-Scientific misconduct check.pdf
Scientific Editor Work List	50677-Scientific editor work list.pdf