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12/6/2019 8:06:37 AM | Browse: 113 | Download: 100
Publication Name World Journal of Gastroenterology
Manuscript ID 50795
Country/Territory China
Received
2019-08-09 09:59
Peer-Review Started
2019-08-09 10:00
To Make the First Decision
2019-09-19 06:50
Return for Revision
2019-09-20 07:38
Revised
2019-10-03 09:47
Second Decision
2019-11-12 10:50
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-13 01:52
Articles in Press
2019-11-13 01:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-11-25 03:52
Typeset the Manuscript
2019-12-02 10:47
Publish the Manuscript Online
2019-12-06 08:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Immunology
Manuscript Type Basic Study
Article Title <Italic>Toxoplasma</Italic> ROP16I/III ameliorated inflammatory bowel diseases via inducing M2 phenotype of macrophages
Manuscript Source Unsolicited Manuscript
All Author List Yong-Wei Xu, Rui-Xin Xing, Wen-Hui Zhang, Lu Li, Yi Wu, Jing Hu, Cong Wang, Qing-Li Luo, Ji-Long Shen and Xi Chen
ORCID
Author(s) ORCID Number
Yong-Wei Xu http://orcid.org/0000-0002-7416-4281
Rui-Xin Xing http://orcid.org/0000-0003-0799-8320
Wen-Hui Zhang http://orcid.org/0000-0002-5344-3396
Lu Li http://orcid.org/0000-0001-5091-0510
Yi Wu http://orcid.org/0000-0002-1663-0758
Jing Hu http://orcid.org/0000-0003-4263-3386
Cong Wang http://orcid.org/0000-0002-5122-8502
Qing-Li Luo http://orcid.org/0000-0003-1153-6241
Ji-Long Shen http://orcid.org/0000-0002-4755-3687
Xi Chen http://orcid.org/0000-0002-2720-8843
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81471983
Key Research and Development Plan Project of Anhui Province, Department of Science and Technology 2019 201904a07020043
Key Project of Natural Science Research in the Universities of Anhui Provence KJ2017A202
Research Fund Project of Anhui Institute of Transforming Medicine 2017zhyx04
Corresponding author Xi Chen, MD, PhD, Chief Doctor, Dean, Director, Doctor, Instructor, Professor, Senior Researcher, Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Department of Gastroenterology, the First Affiliated Hospital of Anhui Medical University, Anhui Province, China., Hefei 230022, Anhui Province, China. ayfychenxi@163.com
Keywords Toxoplasma ROP16Ⅰ/Ⅲ; Caco-2; Inflammatory bowel disease; Immunity; Classically activated macrophages; Alternatively activated macrophages
Core Tip Toxoplasma ROP16Ⅰ/Ⅲ (ToxoROP16Ⅰ/Ⅲ) induced RAW264.7 polarization to M2 macrophage, down-regulation the M1 associated inflammation response and protective Caco-2 intestinal epithelial cells. ToxoROP16Ⅰ/Ⅲ can phosphorylate and activate the transcription factors signal transducer and activator of signal transducer and activator of transcription (Stat) 3 and Stat6, promote the polarization of M2 cells, enhance the synthesis of arginase-1, interleukin (IL)-10, transforming growth factor-β1, and IL-13. M2 mixed with M1 macrophage cells, down-regulation the proinflammatory factors IL-1β, tumour necrosis factor-α, IL-6, nitric oxide (NO), and inducible NO synthase. Then co-culture with Caco-2 cells through transwell, alleviated Caco-2 cell apoptosis and caspase-3, -8, and -9 associated proteins. So this study aims to identify that ToxoROP16Ⅰ/Ⅲ may provide a novel strategy for IBD immunotherapy with parasite-derived effector molecules.
Publish Date 2019-12-06 08:06
Citation Xu YW, Xing RX, Zhang WH, Li L, Wu Y, Hu J, Wang C, Luo QL, Shen JL, Chen X. Toxoplasma ROP16I/III ameliorated inflammatory bowel diseases via inducing M2 phenotype of macrophages. World J Gastroenterol 2019; 25(45): 6634-6652
Url https://www.wjgnet.com/1007-9327/full/v25/i45/6634.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i45.6634
Full Article (PDF) WJG-25-6634.pdf
Full Article (Word) WJG-25-6634.docx
Manuscript File 50795-Review-EditedF.docx
Answering Reviewers 50795-Answering reviewers.pdf
Audio Core Tip 50795-Audio core tip.m4a
Biostatistics Review Certificate 50795-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 50795-Conflict-of-interest statement.pdf
Copyright License Agreement 50795-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 50795-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 50795-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 50795-Language certificate.pdf
Peer-review Report 50795-Peer-review(s).pdf
Scientific Misconduct Check 50795-Bing-Tang JZ-2.png
Scientific Misconduct Check 50795-Scientific misconduct check.pdf
Scientific Editor Work List 50795-Scientific editor work list.pdf