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12/14/2019 11:18:56 AM | Browse: 670 | Download: 926
Publication Name World Journal of Gastroenterology
Manuscript ID 50829
Country/Territory China
Received
2019-08-13 13:21
Peer-Review Started
2019-08-13 13:21
To Make the First Decision
2019-09-12 01:58
Return for Revision
2019-09-12 09:16
Revised
2019-10-15 06:43
Second Decision
2019-10-16 12:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-10-21 18:14
Articles in Press
2019-10-21 18:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-12-11 00:01
Typeset the Manuscript
2019-12-13 06:37
Publish the Manuscript Online
2019-12-14 11:18
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Basic Study
Article Title Aberrant methylation of <Italic>SPARC</Italic> gene and its significance in gastric cancer
Manuscript Source Unsolicited Manuscript
All Author List Shuai Shao, Nuo-Ming Zhou and Dong-Qiu Dai
ORCID
Author(s) ORCID Number
Shuai Shao http://orcid.org/0000-0003-3454-5845
Nuo-Ming Zhou http://orcid.org/0000-0001-7718-2197
Dong-Qiu Dai http://orcid.org/0000-0002-1154-3276
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Liaoning Province 201602817
Corresponding Author Dong-Qiu Dai, MD, PhD, Chief Doctor, Professor, Surgical Oncologist, Department of Gastrointestinal Surgery, the Fourth Affiliated Hospital of China Medical University, Chongshan East Road 4, Shenyang 110032, Liaoning Province, China. daidq63@163.com
Key Words Gastric cancer; Secreted protein acidic and rich in cysteine; Hypermethylation; Clinicopathological features; Tumor suppressor gene;
Core Tip We identified 4 GC cell lines and 66 paired tissues through qRT-PCR, Western blotting and MSP. Low levels of SPARC expression and high levels of methylation in GC tissues were associated with poor clinical features and prognosis. Restoration of SPARC suppressed GC cell proliferation, migration, and invasion, arrested the cell cycle, and increased GC cell apoptosis. Our study found that SPARC could be a target for treating GC individuals.
Publish Date 2019-12-14 11:18
Citation Shao S, Zhou NM, Dai DQ. Aberrant methylation of SPARC gene and its significance in gastric cancer. World J Gastroenterol 2019; 25(46): 6713-6727
URL https://www.wjgnet.com/1007-9327/full/v25/i46/6713.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i46.6713
Full Article (PDF) WJG-25-6713.pdf
Full Article (Word) WJG-25-6713.docx
The ARRIVE Guidelines 50829-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 50829-Review_Filipodia.doc
Answering Reviewers 50829-Answering reviewers.pdf
Audio Core Tip 50829-Audio core tip.mp3
Biostatistics Review Certificate 50829-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 50829-Conflict-of-interest statement.pdf
Copyright License Agreement 50829-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 50829-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 50829-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 50829-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 50829-Language certificate.pdf
Peer-review Report 50829-Peer-review(s).pdf
Scientific Misconduct Check 50829-Scientific misconduct check.pdf
Scientific Editor Work List 50829-Scientific editor work list.pdf