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Articles Published Processes
12/14/2019 11:18:56 AM | Browse: 821 | Download: 1406
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Received |
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2019-08-13 13:21 |
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Peer-Review Started |
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2019-08-13 13:21 |
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To Make the First Decision |
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2019-09-12 01:58 |
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Return for Revision |
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2019-09-12 09:16 |
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Revised |
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2019-10-15 06:43 |
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Second Decision |
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2019-10-16 12:46 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-10-21 18:14 |
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Articles in Press |
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2019-10-21 18:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-12-11 00:01 |
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Typeset the Manuscript |
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2019-12-13 06:37 |
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Publish the Manuscript Online |
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2019-12-14 11:18 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Aberrant methylation of <Italic>SPARC</Italic> gene and its significance in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shuai Shao, Nuo-Ming Zhou and Dong-Qiu Dai |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Liaoning Province |
201602817 |
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| Corresponding Author |
Dong-Qiu Dai, MD, PhD, Chief Doctor, Professor, Surgical Oncologist, Department of Gastrointestinal Surgery, the Fourth Affiliated Hospital of China Medical University, Chongshan East Road 4, Shenyang 110032, Liaoning Province, China. daidq63@163.com |
| Key Words |
Gastric cancer; Secreted protein acidic and rich in cysteine; Hypermethylation; Clinicopathological features; Tumor suppressor gene; |
| Core Tip |
We identified 4 GC cell lines and 66 paired tissues through qRT-PCR, Western
blotting and MSP. Low levels of SPARC expression and high levels of methylation in GC tissues were associated with poor clinical features and prognosis. Restoration of SPARC suppressed GC cell proliferation, migration, and invasion, arrested the cell cycle, and increased GC cell apoptosis. Our study found that SPARC could be a target for treating GC individuals. |
| Publish Date |
2019-12-14 11:18 |
| Citation |
Shao S, Zhou NM, Dai DQ. Aberrant methylation of SPARC gene and its significance in gastric cancer. World J Gastroenterol 2019; 25(46): 6713-6727 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i46/6713.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i46.6713 |
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