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Articles Published Processes
12/12/2019 12:15:56 AM | Browse: 1191 | Download: 1622
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Received |
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2019-08-14 08:01 |
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Peer-Review Started |
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2019-08-14 08:02 |
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To Make the First Decision |
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2019-09-03 05:01 |
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Return for Revision |
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2019-09-18 06:42 |
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Revised |
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2019-09-30 05:47 |
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Second Decision |
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2019-10-18 07:11 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-10-18 22:59 |
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Articles in Press |
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2019-10-18 22:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2019-12-04 06:31 |
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Publish the Manuscript Online |
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2019-12-12 00:15 |
| ISSN |
2218-5836 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Orthopedics |
| Manuscript Type |
Basic Study |
| Article Title |
Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Blake J Schultz, Timothy Sweeney, Malcolm R DeBaun, Melissa Remmel Remmel, Uros Midic, Purvesh Khatri and Michael J Gardner |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Blake J Schultz, MD, Surgeon, Orthopaedics, Stanford University, 450 Broadway Street Pavilion C, 4th Floor, Redwood City, CA 94063, United States. blakeschultzmd@gmail.com |
| Key Words |
Biomarkers; Bioinformatics; Infection; Septic arthritis; Medical technology; Diagnostics |
| Core Tip |
Acute septic arthritis is an orthopedic emergency. The current gold standard diagnostic tool is synovial fluid culture, but this can take days to results, so decisions about surgery are made with imperfect information. A novel diagnostic “Sepsis MetaScore” (SMS) based on an mRNA signature has been identified that uses a blood sample to rapidly identify differentiate septic vs aseptic inflammation. Our pilot study showed the SMS had higher diagnostic accuracy than current standard of care inflammatory labs, showing potential for use as a rule-out test for septic arthritis, helping to minimize misdiagnosis and avoid unnecessary surgeries. |
| Publish Date |
2019-12-12 00:15 |
| Citation |
Schultz BJ, Sweeney T, DeBaun MR, Remmel M, Midic U, Khatri P, Gardner MJ. Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis. World J Orthop 2019; 10(12): 424-433 |
| URL |
https://www.wjgnet.com/2218-5836/full/v10/i12/424.htm |
| DOI |
https://dx.doi.org/10.5312/wjo.v10.i12.424 |
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