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Articles Published Processes
11/26/2019 7:21:43 AM | Browse: 895 | Download: 1723
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Received |
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2019-09-08 12:49 |
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Peer-Review Started |
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2019-09-08 12:49 |
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To Make the First Decision |
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2019-10-24 09:29 |
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Return for Revision |
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2019-10-30 00:59 |
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Revised |
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2019-11-03 03:58 |
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Second Decision |
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2019-11-14 06:48 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2019-11-15 01:54 |
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Articles in Press |
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2019-11-15 01:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-11-21 11:20 |
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Typeset the Manuscript |
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2019-11-22 07:43 |
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Publish the Manuscript Online |
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2019-11-26 07:21 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Case Control Study |
| Article Title |
Human podocyte injury in the early course of hypertensive renal injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Da Sun, Jiao-Jiao Wang, Wei Wang, Juan Wang, Li-Ning Wang, Li Yao, Ying-Hui Sun and Zi-Long Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Liaoning Provincial Department of Science and Technology |
2017225020 |
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| Corresponding Author |
Ying-Hui Sun, MD, Associate Chief Physician, Department of Experimental Medicine, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110016, Liaoning Province, China. yinghui_sun@163.com |
| Key Words |
Podocyte; Hypertension; Hypertensive renal injury; Microalbuminuria; Nephrin; CD2-associated protein |
| Core Tip |
Podocytes probably play a crucial role in the pathogenesis of hypertensive renal injury, but human data are limited. In this study, we detected podocytes from urine sediments of patients with chronic hypertension and trace proteinuria, and obtained direct evidence that podocyte loss is not only associated with severe renal damage in chronic hypertension, but also occurs in the early course of hypertensive renal injury. We found that intrarenal expression of nephrin and CD2-associated protein was downregulated and consistent with podocyte shedding. |
| Publish Date |
2019-11-26 07:21 |
| Citation |
Sun D, Wang JJ, Wang W, Wang J, Wang LN, Yao L, Sun YH, Li ZL. Human podocyte injury in the early course of hypertensive renal injury. World J Clin Cases 2019; 7(22): 3698-3710 |
| URL |
https://www.wjgnet.com/2307-8960/full/v7/i22/3698.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v7.i22.3698 |
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