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11/26/2019 7:21:43 AM | Browse: 756 | Download: 1247
Publication Name World Journal of Clinical Cases
Manuscript ID 51045
Country China
Received
2019-09-08 12:49
Peer-Review Started
2019-09-08 12:49
To Make the First Decision
2019-10-24 09:29
Return for Revision
2019-10-30 00:59
Revised
2019-11-03 03:58
Second Decision
2019-11-14 06:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-15 01:54
Articles in Press
2019-11-15 01:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-11-21 11:20
Typeset the Manuscript
2019-11-22 07:43
Publish the Manuscript Online
2019-11-26 07:21
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Urology & Nephrology
Manuscript Type Case Control Study
Article Title Human podocyte injury in the early course of hypertensive renal injury
Manuscript Source Unsolicited Manuscript
All Author List Da Sun, Jiao-Jiao Wang, Wei Wang, Juan Wang, Li-Ning Wang, Li Yao, Ying-Hui Sun and Zi-Long Li
ORCID
Author(s) ORCID Number
Da Sun http://orcid.org/0000-0002-5822-5195
Jiao-Jiao Wang http://orcid.org/0000-0003-2827-1622
Wei Wang http://orcid.org/0000-0003-4743-3308
Juan Wang http://orcid.org/0000-0001-7326-9922
Li-Ning Wang http://orcid.org/0000-0001-6173-3361
Li Yao http://orcid.org/0000-0002-2460-7283
Ying-Hui Sun http://orcid.org/0000-0003-1751-3227
Zi-Long Li http://orcid.org/0000-0002-2187-2874
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Liaoning Provincial Department of Science and Technology 2017225020
Corresponding Author Ying-Hui Sun, MD, Associate Chief Physician, Department of Experimental Medicine, General Hospital of Northern Theater Command, No. 83 Wenhua Road, Shenhe District, Shenyang 110016, Liaoning Province, China. yinghui_sun@163.com
Key Words Podocyte; Hypertension; Hypertensive renal injury; Microalbuminuria; Nephrin; CD2-associated protein
Core Tip Podocytes probably play a crucial role in the pathogenesis of hypertensive renal injury, but human data are limited. In this study, we detected podocytes from urine sediments of patients with chronic hypertension and trace proteinuria, and obtained direct evidence that podocyte loss is not only associated with severe renal damage in chronic hypertension, but also occurs in the early course of hypertensive renal injury. We found that intrarenal expression of nephrin and CD2-associated protein was downregulated and consistent with podocyte shedding.
Publish Date 2019-11-26 07:21
Citation Sun D, Wang JJ, Wang W, Wang J, Wang LN, Yao L, Sun YH, Li ZL. Human podocyte injury in the early course of hypertensive renal injury. World J Clin Cases 2019; 7(22): 3698-3710
URL https://www.wjgnet.com/2307-8960/full/v7/i22/3698.htm
DOI https://dx.doi.org/10.12998/wjcc.v7.i22.3698
Full Article (PDF) WJCC-7-3698.pdf
Full Article (Word) WJCC-7-3698.docx
STROBE Statement 51045-STROBE-Statement-revision.pdf
Manuscript File 51045-Review-Tracked.docx
Answering Reviewers 51045-Answering reviewers.pdf
Audio Core Tip 51045-Audio core tip.m4a
Biostatistics Review Certificate 51045-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51045-Conflict-of-interest statement.pdf
Copyright License Agreement 51045-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 51045-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 51045-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 51045-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51045-Language certificate.pdf
Peer-review Report 51045-Peer-review(s).pdf
Scientific Misconduct Check 51045-Scientific misconduct check.pdf
Scientific Editor Work List 51045-Scientific editor work list.pdf