Publication Name	World Journal of Gastroenterology
Manuscript ID	5116
Country	Germany

Received	2013-08-16 08:30
Peer-Review Started	2013-08-16 11:11
To Make the First Decision	2013-09-02 16:12
Return for Revision	2013-09-04 13:33
Revised	2013-09-13 14:03
Second Decision	2013-10-14 09:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-14 13:30
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-02-13 16:46
Publish the Manuscript Online	2014-03-12 11:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver
Manuscript Source	Invited Manuscript
All Author List	Salamah Mohammad Alwahsh, Min Xu, Hatice Ali Seyhan, Shakil Ahmad, Sabine Mihm, Giuliano Ramadori and Frank Christian Schultze
Funding Agency and Grant Number
Corresponding Author	Frank Christian Schultze, MD, Department of Gastroenterology and Endocrinology, University Medical Center Goettingen, Robert-Koch-Str. 40, 37075 Goettingen, Germany. f.schultze@med.uni-goettingen.de
Key Words	Non-alcoholic fatty liver disease; Inflammation; Endotoxins; Lipopolysaccharide; Oxidative stress; Mitochondrial dysfunction; Metabolic syndrome
Core Tip	Both Lieber-DeCarli (LDC) and LDC + 70% cal fructose (L-HFr) models featured fatty liver. Fructose-enriched regimen induced metabolic syndrome in the corresponding rats. Lipocalin-2 (LCN-2) was strikingly increased in the liver and serum of the L-HFr group. In this group, the increase of LCN-2 synthesis was associated with inflammation at week 4, whereas the peak value of LCN-2 at week 8 was mainly accompanied by impairment of the mitochondrial function. Nevertheless, an interaction coexists between both processes. The indicators of stress conditions and apoptosis were elevated at both time points. Evidently, the expression of LCN-2 was correlated to inflammatory and metabolic processes.
Publish Date	2014-03-12 11:24
Citation	Alwahsh SM, Xu M, Seyhan HA, Ahmad S, Mihm S, Ramadori G, Schultze FC. Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver. World J Gastroenterol 2014; 20(7): 1807-1821
URL	http://www.wjgnet.com/1007-9327/full/v20/i7/1807.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i7.1807

Full Article (PDF)	WJG-20-1807.pdf
Full Article (Word)	WJG-20-1807.doc
Manuscript File	5116-Review.docx
Answering Reviewers	5116-Answering reviewers.pdf
Copyright License Agreement	5116-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5116-Language certificate.pdf
Peer-review Report	5116-Peer review.pdf
Scientific Editor Work List	5116-Scientific editor work list.doc