| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Observational Study |
| Article Title |
Relationship between β-amyloid protein 1-42, thyroid hormone levels and the risk of cognitive impairment after ischemic stroke
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Lei Mao, Xiao-Han Chen, Jian-Hua Zhuang, Peng Li, Yi-Xin Xu, Yu-Chen Zhao, Yue-Jin Ma, Bin He and You Yin |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Support Projects in Biomedicine Field of Shanghai Science and Technology Commission |
19441907500 |
| Naval Medical University military medical innovation |
2017JS07 |
| Science and Technology Action Innovation program by Science and Technology Commission of Shanghai |
17411950104 |
|
| Corresponding Author |
You Yin, MD, PhD, Chief Doctor, Chief Physician, Department of Neurology, Changzheng Hospital, the PLA Naval Medical University, NO. 415 Fengyang Road, Huangpu District, Shanghai 200003, China. yinyou179@163.com |
| Key Words |
Post-stroke cognitive impairment; Triiodothyronine; β-amyloid protein; Prognosis; Montreal cognitive assessment; Free thyroxin |
| Core Tip |
Post-stroke cognitive impairment (PSCI) has become a deepening public health problem, resulting in a sustained increase in the global social and economic burden. Clinical diagnosis of PSCI is mostly based on clinical manifestations, neuroimaging and a series of neuropsychological tests, but the sensitivity of early recognition of PSCI is not significant, because the implementation of the above-mentioned scheme mainly depends on the cooperation of patients. Therefore, it is extremely necessary to identify early biomarkers. Our study found that β-amyloid protein 1-42 (Aß1-42) and triiodothyronine (T3) can dynamically monitor the patient's clinical status, and have a good correlation with the progress of the disease. It is suggested that Aß1-42 and T3 have the ability to predict the progress of PSCI and have a broad application prospect. |
| Publish Date |
2020-01-07 01:54 |
| Citation |
Mao L, Chen XH, Zhuang JH, Li P, Xu YX, Zhao YC, Ma YJ, He B, Yin Y. Relationship between β-amyloid protein 1-42, thyroid hormone levels and the risk of cognitive impairment after ischemic stroke. World J Clin Cases 2020; 8(1): 76-87 |
| URL |
https://www.wjgnet.com/2307-8960/full/v8/i1/76.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v8.i1.76 |
