Publication Name	World Journal of Gastroenterology
Manuscript ID	5132
Country	China

Received	2013-08-17 15:58
Peer-Review Started	2013-08-18 19:37
First Decision by Editorial Office Director
Return for Revision	2013-09-17 14:58
Revised	2013-10-14 11:01
Publication Fee Transferred
Second Decision by Editor	2013-11-18 20:49
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-11-19 11:55
Articles in Press
Edit the Manuscript by Language Editor	2013-12-10 15:49
Typeset the Manuscript	2014-01-12 18:32
Publish the Manuscript Online	2014-01-26 20:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Autobiography
Article Title	Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease
Manuscript Source	Invited Manuscript
All Author List	Chao Wang, Juan Han, Liang Xiao, Chang-E Jin, Dong-Jian Li and Zhen Yang
Funding Agency and Grant Number	Funding Agency Grant Number Research Fund for the Doctoral Program of Higher Education of China 20120142120048 Natural Science Foundation of Hubei Province, China 2012FFB02308
Corresponding Author	Chao Wang, PhD, Department of General Surgery, Tongji Hospital, Tongji Medical College, Science and Technology of Huazhong University, No. 1095, Jiefang Avenue, Wuhan 430030, Hubei Province, China. wangchao75@sina.com
Key Words	Portal hypertension; Apoptosis; B-cell lymphoma-2; B-cell lymphoma-XL; Cystathionine γ-lyase; pERK 1/2; Hydrogen sulfide
Core Tip	In portal hypertension patients, endogenous hydrogen sulfide (H2S) levels were significantly lower than those in healthy controls. H2S plasma level reductions correlated with portal vein diameter and Child-Pugh score. In a rabbit hepatic schistosomiasis portal hypertension model, liver tissue H2S concentrations and cystathionine γ-lyase expression were significantly reduced and phosphorylated extracellular signal regulated kinase 1/2 expression gradually increased. Increasing H2S levels led to increased apoptosis of portal vein smooth muscle cells, while B-cell lymphoma-2 (Bcl-2) and Bcl-XL expression decreased. We suggest that H2S prevents portal hypertension though apoptosis induction of otherwise excessive proliferating smooth muscle cells.
Publish Date	2014-01-26 20:08
Citation	Wang C, Han J, Xiao L, Jin CE, Li DJ, Yang Z. Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease. World J Gastroenterol 2014; 20(4): 1079-1087
URL	http://www.wjgnet.com/1007-9327/full/v20/i4/1079.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i4.1079

Full Article (PDF)	WJG-20-1079.pdf
Full Article (Word)	WJG-20-1079.doc
Manuscript File	5132-Review.docx
Answering Reviewers	5132-Answering Reviewers.pdf
Copyright License Agreement	5132-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5132-Language certificate.PDF
Peer-review Report	5132-Peer reviews.pdf
Scientific Editor Work List	5132-Scientific editor work list.doc