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Articles Published Processes
9/3/2014 5:13:00 PM | Browse: 897 | Download: 810
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Received |
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2013-08-17 15:58 |
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Peer-Review Started |
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2013-08-18 19:37 |
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To Make the First Decision |
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2013-09-16 20:26 |
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Return for Revision |
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2013-09-17 14:58 |
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Revised |
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2013-10-14 11:01 |
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Second Decision |
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2013-11-18 20:49 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2013-11-19 11:55 |
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Articles in Press |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2013-12-10 15:49 |
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Typeset the Manuscript |
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2014-01-12 18:32 |
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Publish the Manuscript Online |
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2014-01-26 20:08 |
| Category |
Surgery |
| Manuscript Type |
Autobiography |
| Article Title |
Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chao Wang, Juan Han, Liang Xiao, Chang-E Jin, Dong-Jian Li and Zhen Yang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Fund for the Doctoral Program of Higher Education of China |
20120142120048 |
| Natural Science Foundation of Hubei Province, China |
2012FFB02308 |
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| Corresponding Author |
Chao Wang, PhD, Department of General Surgery, Tongji Hospital, Tongji Medical College, Science and Technology of Huazhong University, No. 1095, Jiefang Avenue, Wuhan 430030, Hubei Province, China. wangchao75@sina.com |
| Key Words |
Portal hypertension; Apoptosis; B-cell lymphoma-2; B-cell lymphoma-XL; Cystathionine γ-lyase; pERK 1/2; Hydrogen sulfide |
| Core Tip |
In portal hypertension patients, endogenous hydrogen sulfide (H2S) levels were significantly lower than those in healthy controls. H2S plasma level reductions correlated with portal vein diameter and Child-Pugh score. In a rabbit hepatic schistosomiasis portal hypertension model, liver tissue H2S concentrations and cystathionine γ-lyase expression were significantly reduced and phosphorylated extracellular signal regulated kinase 1/2 expression gradually increased. Increasing H2S levels led to increased apoptosis of portal vein smooth muscle cells, while B-cell lymphoma-2 (Bcl-2) and Bcl-XL expression decreased. We suggest that H2S prevents portal hypertension though apoptosis induction of otherwise excessive proliferating smooth muscle cells. |
| Publish Date |
2014-01-26 20:08 |
| Citation |
Wang C, Han J, Xiao L, Jin CE, Li DJ, Yang Z. Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease. World J Gastroenterol 2014; 20(4): 1079-1087 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i4/1079.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i4.1079 |
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