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Articles Published Processes
12/6/2019 8:06:37 AM | Browse: 1232 | Download: 3190
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Received |
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2019-09-17 08:33 |
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Peer-Review Started |
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2019-09-17 08:34 |
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First Decision by Editorial Office Director |
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2019-11-04 06:02 |
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Return for Revision |
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2019-11-05 00:22 |
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Revised |
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2019-11-08 04:50 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2019-11-15 11:38 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2019-11-16 02:14 |
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Articles in Press |
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2019-11-16 02:14 |
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Edit the Manuscript by Language Editor |
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2019-11-27 00:17 |
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Typeset the Manuscript |
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2019-12-02 10:46 |
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Publish the Manuscript Online |
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2019-12-06 08:06 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Irisin attenuates intestinal injury, oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Fan Ren, Meng-Zhou Wang, Jian-Bin Bi, Jia Zhang, Lin Zhang, Wu-Ming Liu, Sha-Sha Wei, Yi Lv, Zheng Wu and Rong-Qian Wu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
81770491 |
| Ministry of Education Innovation Team Development Program of China |
IRT16R57 |
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| Corresponding Author |
Rong-Qian Wu, MD, PhD, Professor, National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi'an Jiaotong University, No. 76 West Yanta Road, Xi’an 710061, Shaanxi Province, China. rwu001@mail.xjtu.edu.cn |
| Key Words |
Irisin; Intestinal injury; Oxidative stress; Endoplasmic reticulum stress; Acute pancreatitis; Mouse model |
| Core Tip |
In this study, we reported for the first time that intraperitoneal injection of irisin could relieve intestinal injury in mice with acute pancreatitis (AP). AP was induced in male adult mice by 2 hourly intraperitoneal injections of L-arginine. At 2 h after the last injection of L-arginine, irisin (50 or 250 μg/kg body weight) or 1 mL normal saline (vehicle) was administered through intraperitoneal injection. Irisin alleviates intestinal and systemic inflammatory reactions by inhibiting intestinal endoplasmic reticulum stress and oxidative stress in mice with AP, reduces the degree of intestinal tissue apoptosis and injury, and finally alleviates the condition of pancreatitis. |
| Publish Date |
2019-12-06 08:06 |
| Citation |
Ren YF, Wang MZ, Bi JB, Zhang J, Zhang L, Liu WM, Wei SS, Lv Y, Wu Z, Wu RQ. Irisin attenuates intestinal injury, oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis. World J Gastroenterol 2019; 25(45): 6653-6667 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i45/6653.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i45.6653 |
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