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12/6/2019 8:06:37 AM | Browse: 755 | Download: 1636
Publication Name World Journal of Gastroenterology
Manuscript ID 51410
Country/Territory China
Received
2019-09-17 08:33
Peer-Review Started
2019-09-17 08:34
To Make the First Decision
2019-11-04 07:40
Return for Revision
2019-11-05 00:22
Revised
2019-11-08 04:50
Second Decision
2019-11-15 11:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-11-16 02:14
Articles in Press
2019-11-16 02:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-11-27 00:17
Typeset the Manuscript
2019-12-02 10:46
Publish the Manuscript Online
2019-12-06 08:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Irisin attenuates intestinal injury, oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis
Manuscript Source Unsolicited Manuscript
All Author List Yi-Fan Ren, Meng-Zhou Wang, Jian-Bin Bi, Jia Zhang, Lin Zhang, Wu-Ming Liu, Sha-Sha Wei, Yi Lv, Zheng Wu and Rong-Qian Wu
ORCID
Author(s) ORCID Number
Yi-Fan Ren http://orcid.org/0000-0003-0907-2900
Meng-Zhou Wang http://orcid.org/0000-0003-3357-656X
Jian-Bin Bi http://orcid.org/0000-0002-9281-1999
Jia Zhang http://orcid.org/0000-0001-7306-3350
Lin Zhang http://orcid.org/0000-0003-3927-2997
Wu-Ming Liu http://orcid.org/0000-0001-5550-0916
Sha-Sha Wei http://orcid.org/0000-0001-8490-6026
Yi Lv http://orcid.org/0000-0002-7104-2414
Zheng Wu http://orcid.org/0000-0002-7102-9543
Rong-Qian Wu http://orcid.org/0000-0003-0993-4531
Funding Agency and Grant Number
Funding Agency Grant Number
National Nature Science Foundation of China 81770491
Ministry of Education Innovation Team Development Program of China IRT16R57
Corresponding Author Rong-Qian Wu, MD, PhD, Professor, National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine, First Affiliated Hospital of Xi'an Jiaotong University, No. 76 West Yanta Road, Xi’an 710061, Shaanxi Province, China. rwu001@mail.xjtu.edu.cn
Key Words Irisin; Intestinal injury; Oxidative stress; Endoplasmic reticulum stress; Acute pancreatitis; Mouse model
Core Tip In this study, we reported for the first time that intraperitoneal injection of irisin could relieve intestinal injury in mice with acute pancreatitis (AP). AP was induced in male adult mice by 2 hourly intraperitoneal injections of L-arginine. At 2 h after the last injection of L-arginine, irisin (50 or 250 μg/kg body weight) or 1 mL normal saline (vehicle) was administered through intraperitoneal injection. Irisin alleviates intestinal and systemic inflammatory reactions by inhibiting intestinal endoplasmic reticulum stress and oxidative stress in mice with AP, reduces the degree of intestinal tissue apoptosis and injury, and finally alleviates the condition of pancreatitis.
Publish Date 2019-12-06 08:06
Citation Ren YF, Wang MZ, Bi JB, Zhang J, Zhang L, Liu WM, Wei SS, Lv Y, Wu Z, Wu RQ. Irisin attenuates intestinal injury, oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis. World J Gastroenterol 2019; 25(45): 6653-6667
URL https://www.wjgnet.com/1007-9327/full/v25/i45/6653.htm
DOI https://dx.doi.org/10.3748/wjg.v25.i45.6653
Full Article (PDF) WJG-25-6653.pdf
Full Article (Word) WJG-25-6653.docx
The ARRIVE Guidelines 51410-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 51410-Review-FP7088_ce16_CE1MS_edit2.docx
Answering Reviewers 51410-Answering reviewers.pdf
Audio Core Tip 51410-Audio core tip.mp3
Biostatistics Review Certificate 51410-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51410-Conflict-of-interest statement.pdf
Copyright License Agreement 51410-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 51410-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 51410-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 51410-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 51410-Language certificate.pdf
Supplementary Material 51410-Supplementary material.pdf
Peer-review Report 51410-Peer-review(s).pdf
Scientific Misconduct Check 51410-Bing-Tang JZ-2.png
Scientific Misconduct Check 51410-Scientific misconduct check.pdf
Scientific Editor Work List 51410-Scientific editor work list.pdf