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Articles Published Processes
3/16/2020 11:58:14 PM | Browse: 816 | Download: 1022
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Received |
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2019-09-20 14:26 |
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Peer-Review Started |
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2019-09-20 14:26 |
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To Make the First Decision |
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Return for Revision |
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2019-12-06 01:29 |
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Revised |
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2020-01-02 13:37 |
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Second Decision |
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2020-02-27 11:25 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-03-01 22:59 |
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Articles in Press |
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2020-03-01 22:59 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-03-13 08:31 |
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Publish the Manuscript Online |
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2020-03-16 23:58 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article which was selected byan in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Roles of cell fusion, hybridization and polyploid cell formation in cancer metastasis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ivan Shabo, Joar Svanvik, Annelie Lindström, Tanguy Lechertier, Sara Trabulo, James Hulit, Tim Sparey and John Pawelek |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ivan Shabo, MD, PhD, Associate Professor, Surgeon, Endocrine and Sarcoma Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm Nobels väg 6, Sockholm SE 171 77, Sweden. ivan.shabo@ki.se |
| Key Words |
Cell fusion; Hybrid formation; Polyploidization; Macrophage; Cancer progression; Oncologic treatment resistance |
| Core Tip |
Cell fusion is a normal biological process involved in organ formation and tissue repair. Through cell fusion, somatic cells undergo nuclear reprogramming and epigenetic modifications to form hybrid cells with new properties. Fusion of cancer cells with macrophages plays a major role in cancer metastasis and results in resistance to chemo- and radiation therapy. Cell fusion might be a potential target for the development of new anti-tumoural therapies through macrophage depletion in tumour stroma and prevention of cell fusion and post-hybridization events involving chemotaxis and cell migration to lymph nodes and distant metastases. |
| Publish Date |
2020-03-16 23:58 |
| Citation |
Shabo I, Svanvik J, Lindström A, Lechertier T, Trabulo S, Hulit J, Sparey T, Pawelek J. Roles of cell fusion, hybridization and polyploid cell formation in cancer metastasis. World J Clin Oncol. 2020; 11(3): 121-135 |
| URL |
https://www.wjgnet.com/2218-4333/full/v11/i3/121.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v11.i3.121 |
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