| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Non-SMC condensin I complex subunit D2 and non-SMC condensin II complex subunit D3 induces inflammation via the IKK/NF-κB pathway in ulcerative colitis
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Chang-Wen Yuan, Xue-Liang Sun, Li-Chao Qiao, Hai-Xia Xu, Ping Zhu, Hong-Jin Chen and Bo-Lin Yang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81673973 |
| Natural Science Foundation of Jiangsu Province, China |
BK20161577 |
| Developing Program for High-level Academic Talent from Jiangsu Hospital of Chinese Medicine |
y2018rc16 |
|
| Corresponding Author |
Bo-Lin Yang, MD, Chief Doctor, Professor, Surgeon, Department of colorectal Surgery, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. yfy0051@njucm.edu.cn |
| Key Words |
Non-SMC condensin I complex subunit D2; Non-SMC condensin II complex subunit D3; Ulcerative colitis; Inflammation; IKK/NF-κB; Pathway |
| Core Tip |
In this study, non-SMC condensin I complex subunit D2 (NCAPD2) and non-SMC condensin II complex subunit D3 (NCAPD3) expressions has been confirmed to be significantly up-regulated in the intestinal mucosa of patients with active UC. In vitro, the data suggested that silence of NACPD2 and NACPD3 could obviously depress the expressions of IL-1β, IL-6 and TNF-α. Further, knockdown of NACPD2 and NACPD3 could remarkably suppress the IKK nucleation and NF-κB volume. These results suggested that NACPD2 and NACPD3 were over-expressed in the intestinal mucosa of patients with UC, and overexpression of NCAPD2/3 promotes the release of pro-inflammatory cytokines by modulating the signaling pathway of the IKK/NF-κB. |
| Publish Date |
2019-12-20 10:20 |
| Citation |
Yuan CW, Sun XL, Qiao LC, Xu HX, Zhu P, Chen HJ, Yang BL. Non-SMC condensin I complex subunit D2 and non-SMC condensin II complex subunit D3 induces inflammation via the IKK/NF-κB pathway in ulcerative colitis. World J Gastroenterol 2019; 25(47): 6813-6822 |
| URL |
https://www.wjgnet.com/1007-9327/full/v25/i47/6813.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v25.i47.6813 |
