| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article which selected by an in-house editor and fully peer-reviewed by external reviewers. It distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, General & Internal |
| Manuscript Type |
Prospective Study |
| Article Title |
Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Zsolt Kovacs, Ioan Jung, Krisztina Szalman, Laura Banias, Tivadar Jr Bara and Simona Gurzu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Romanian National Authority for Scientific Research, CNCSIS – UEFISCDI |
20 PCCF/2018 |
|
| Corresponding Author |
Simona Gurzu, MD, PhD, Chief Doctor, Director, Director, Doctor, Doctor, Full Professor, Research Fellow, Research Scientist, Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, “George Emil Palade“, 38 Gheorghe Marinescu Street, Targu Mures 540139, Romania. simonagurzu@yahoo.com |
| Key Words |
Arylsulfatase; Maspin; Colorectal cancer; ARSB gene; Blood; Tissue |
| Core Tip |
In this paper we tried to emphasize the role of ARSA and ARSB in colorectal cancer (CRC) beahaviour and possible role of ARSB serum level in follow-up of patients. This is the first study in literature which proved that a low ARSB gene expression in serum (RQ < 1) might be a non-invasive indicator of risk of CRC. Moreover, triple positivity for maspin/ARSA/ARSB and ARSB gene expression level < 0.5 were proved to be indicators of CRC aggressive behavior, independent of lymph node status. |
| Publish Date |
2019-12-06 11:43 |
| Citation |
Kovacs Z, Jung I, Szalman K, Banias L, Bara TJ, Gurzu S. Interaction of arylsulfatases A and B with maspin: A possible explanation for dysregulation of tumor cell metabolism and invasive potential of colorectal cancer. World J Clin Cases 2020; 7(23): 3990-4003 |
| URL |
https://www.wjgnet.com/2307-8960/full/v7/i23/3990.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v7.i23.3990 |
