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Articles Published Processes
4/23/2020 10:34:55 AM | Browse: 628 | Download: 574
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Received |
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2019-10-11 19:44 |
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Peer-Review Started |
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2019-10-11 19:44 |
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To Make the First Decision |
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2019-11-04 00:38 |
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Return for Revision |
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2019-11-05 00:18 |
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Revised |
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2019-12-26 19:14 |
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Second Decision |
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2020-02-14 02:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2020-02-18 05:52 |
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Articles in Press |
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2020-02-18 05:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-04-02 01:43 |
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Publish the Manuscript Online |
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2020-04-23 10:34 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Liver injury induced by paracetamol and challenges associated with intentional and unintentional use
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Laura Rotundo and Nikolaos Pyrsopoulos |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Nikolaos Pyrsopoulos, FACP, MD, PhD, Doctor, Professor, Department of Medicine, Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Rutgers University, New Jersey Medical School, 185 S. Orange Avenue, MSB H-535, Newark, New Jersey 07103, United States. pyrsopni@njms.rutgers.edu |
| Key Words |
Paracetamol; Drug-induced liver injury; Hepatotoxicity; Acute liver failure; ; |
| Core Tip |
Paracetamol is a widely used anti-pyretic that has long been established to cause liver toxicity once above therapeutic levels. Given the increased prevalence of combination medications in the form of pain relievers and antihistamines, paracetamol can be difficult to identify and remains a significant cause of acute hepatotoxicity globally. This is especially concerning given that, when co-ingested with other medications, the rise in serum paracetamol levels may be delayed and alter medical management. This review serves to describe the clinical and pathophysiologic features of hepatotoxicity secondary to paracetamol and provide an update on current available knowledge and treatment options. |
| Publish Date |
2020-04-23 10:34 |
| Citation |
Rotundo L, Pyrsopoulos N. Liver injury induced by paracetamol and challenges associated with intentional and unintentional use. World J Hepatol 2020; 12(4): 125-136 |
| URL |
https://www.wjgnet.com/1948-5182/full/v12/i4/125.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v12.i4.125 |
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