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Publication Name World Journal of Gastroenterology
Manuscript ID 51827
Country/Territory United States
Received
2019-10-22 16:46
Peer-Review Started
2019-10-15 19:11
To Make the First Decision
Return for Revision
2019-11-27 03:31
Revised
2019-12-11 17:37
Second Decision
2019-12-19 04:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-12-22 12:06
Articles in Press
2019-12-22 12:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2020-01-14 02:03
Publish the Manuscript Online
2020-01-16 07:58
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2020 Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Metabolite profile comparisons between ascending and descending colon tissue in healthy adults
Manuscript Source Unsolicited Manuscript
All Author List Bridget A Baxter, Kristopher D Parker, Michael J Nosler, Sangeeta Rao, Rebecca Craig, Catherine Seiler and Elizabeth P Ryan
ORCID
Author(s) ORCID Number
Bridget A Baxter http://orcid.org/0000-0001-9549-1989
Kristopher D Parker http://orcid.org/0000-0002-6872-1547
Michael J Nosler http://orcid.org/000-0001-9174-0538
Sangeeta Rao http://orcid.org/0000-0002-9234-0082
Rebecca Craig http://orcid.org/0000-0001-6503-746X
Catherine Seiler http://orcid.org/0000-0001-8357-818X
Elizabeth P Ryan http://orcid.org/0000-0002-1577-0919
Funding Agency and Grant Number
Funding Agency Grant Number
the CancerCure Foundation and the University of Colorado Cancer Center Support Grant, Division of Cancer Control and Prevention (Aurora, CO) P30CA046934
Corresponding Author Elizabeth P Ryan, PhD, Associate Professor, Department of Environmental and Radiological Health Sciences, Colorado State University, 1617 Campus Delivery, Fort Collins, CO 80523, United States. e.p.ryan@colostate.edu
Key Words Colon; Ascending; Descending; Metabolomics; Obesity; Stool
Core Tip This study identified metabolite profile differences between right-ascending and left-descending colon from normal, overweight or obese adults. We also show that stool metabolite composition does not accurately reflect the right-ascending colon. There is limited knowledge of human colon small molecules and metabolite signatures that may impact colon cancer risk. Colon cancer of the right-ascending colon has a poorer prognosis and reduced survival outcome when compared to colon cancer on the left-descending colon. Diet and lifestyle are additional factors of overweight and obesity that may influence colon tissue metabolite composition with respect to inflammation. Right and left colon metabolite profiles may be helpful to evaluate after interventions that seek to prevent or mitigate cancer risk.
Publish Date 2020-01-16 07:58
Citation Baxter BA, Parker KJ, Nosler MJ, Rao S, Craig R, Seiler C, Ryan EP. Metabolite profile comparisons between ascending and descending colon tissue in healthy adults. World J Gastroenterol 2020; 26(3): 335-352
URL https://www.wjgnet.com/1007-9327/full/v26/i3/335.htm
DOI https://dx.doi.org/10.3748/wjg.v26.i3.335
Full Article (PDF) WJG-26-335.pdf
Full Article (Word) WJG-26-335.docx
STROBE Statement 51827-STROBE-Statement-revision.pdf
Manuscript File 51827-Review.docx
Answering Reviewers 51827-Answering reviewers.pdf
Audio Core Tip 51827-Audio core tip.m4a
Biostatistics Review Certificate 51827-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 51827-Conflict-of-interest statement.pdf
Copyright License Agreement 51827-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 51827-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 51827-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 51827-Institutional review board statement.pdf
Supplementary Material 51827-Supplementary material.zip
Peer-review Report 51827-Peer-review(s).pdf
Scientific Misconduct Check 51827-Scientific misconduct check.pdf
Scientific Editor Work List 51827-Scientific editor work list.pdf