BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
1/13/2020 11:27:13 AM | Browse: 908 | Download: 1884
 |
Received |
|
2019-10-08 03:16 |
|
Peer-Review Started |
|
2019-10-08 03:16 |
 |
To Make the First Decision |
|
|
|
Return for Revision |
|
2019-11-10 05:19 |
|
Revised |
|
2019-12-14 04:03 |
|
Second Decision |
|
2019-12-19 06:35 |
|
Accepted by Journal Editor-in-Chief |
|
|
|
Accepted by Executive Editor-in-Chief |
|
2019-12-23 10:11 |
|
Articles in Press |
|
2019-12-23 10:11 |
|
Publication Fee Transferred |
|
|
|
Edit the Manuscript by Language Editor |
|
2020-01-05 10:09 |
|
Typeset the Manuscript |
|
2020-01-10 08:45 |
|
Publish the Manuscript Online |
|
2020-01-13 11:27 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Observational Study |
| Article Title |
Impact of reactivation of the GFRA1 gene by DNA demethylation on the prognosis of patients with metastatic colon cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wan-Ru Ma, Peng Xu, Zhao-Jun Liu, Jing Zhou, Lian-Kun Gu, Jun Zhang and Da-Jun Deng |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the National Natural Science Foundation of China A3 Foresight Program |
31261140372 |
| Beijing Science and Technology Commission |
Z151100001615022 |
| the Science Foundation of Peking University Cancer Hospital |
2017-25 |
|
| Corresponding Author |
Da-Jun Deng, MD, Professor, Laboratory of Carcinogenesis and Translational Research (MOE/Beijing), Division of Etiology, Peking University Cancer Hospital and Institute, Fu-Cheng-Lu #52, Haidian District, Beijing 100142, China. dengdajun@bjmu.edu.cn |
| Key Words |
GFRA1; Demethylation; CpG island; Colon cancer; Metastasis; Membrane receptor |
| Core Tip |
GFRA1 reactivation by DNA demethylation is a frequent event in colon cancer (CC) development and that the high level of GFRA1 demethylation in CC tissues is correlated with high metastasis risk of CC and shorter overall survival of patients, especially patients with metastatic CC. We find that GFRA1 overexpression enhances the proliferation and growth of CC cells in vitro and in vivo, probably by activation of the GFRA1-GDNF downstream pathway. These data indicate that reactivation of GFRA1 by DNA demethylation is an important prognosis factor for CC and the cancer-related cell membrane protein GFRA1 may be a therapeutic target for CC patients. |
| Publish Date |
2020-01-13 11:27 |
| Citation |
Ma WR, Xu P, Liu ZJ, Zhou J, Gu LK, Zhang J, Deng DJ. Impact of reactivation of the GFRA1 gene by DNA demethylation on the prognosis of patients with metastatic colon cancer. World J Gastroenterol 2020; 26(2): 184-198 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i2/184.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i2.184 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
