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Articles Published Processes
2/14/2020 11:49:18 AM | Browse: 1011 | Download: 1717
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Received |
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2019-10-15 09:51 |
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Peer-Review Started |
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2019-10-15 09:52 |
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To Make the First Decision |
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Return for Revision |
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2019-12-04 20:08 |
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Revised |
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2019-12-20 12:39 |
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Second Decision |
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2020-01-11 03:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-01-14 19:56 |
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Articles in Press |
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2020-01-14 19:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2020-01-18 23:43 |
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Typeset the Manuscript |
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2020-02-13 00:22 |
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Publish the Manuscript Online |
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2020-02-14 11:49 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Histone deacetylase inhibitor pretreatment enhances efficacy of DNA-interacting chemo-drugs in gastric cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ramchandra Vijay Amnekar, Shafqat Ali Khan, Mudasir Rashid, Bharat Khade, Rahul Thorat, Poonam Gera, Shailesh V Shrikhande, Duane T Smoot, Hassan Ashktorab and Sanjay Gupta |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| TMH-IRG |
466/2012 and 164/2016 |
| LTMT |
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| Corresponding Author |
Sanjay Gupta, PhD, Senior Scientist, Epigenetics and Chromatin Biology Group, Gupta Laboratory, Cancer Research Institute, Advanced Centre for Treatment Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, Maharashtra, India. sgupta@actrec.gov.in |
| Key Words |
Chemotherapy; Combinatorial index; Gastric cancer; Histone acetylation; Histone deacetylase inhibitor; Patient stratification |
| Core Tip |
Our study suggest that pre-treatment with histone deacetylase inhibitors (HDACi) in a pre-clinical model of gastric cancer increase acetylation, opens chromatin and favors binding of DNA interacting chemotherapeutic drugs synergistically. This enhances cytotoxic potential of chemotherapeutic drug at low therapeutic dose and reduces toxicity. The dose response studies using Fa plots and median curve analysis proposes valproic acid as the most synergistic and effective HDACi in combination with platinum based drugs. Further, HDAC expression or activity based patient stratification prior to HDACi therapy has been put forth for better clinical outcome of chemotherapeutic drugs in solid tumors. |
| Publish Date |
2020-02-14 11:49 |
| Citation |
Amnekar RV, Khan SA, Rashid M, Khade B, Thorat R, Gera P, Shrikhande SV, Smoot DT, Ashktorab H and Gupta S. Histone deacetylase inhibitor pretreatment enhances efficacy of DNA-interacting chemo-drugs in gastric cancer. World J Gastroenterol 2020; 26(6): 598-613 |
| URL |
https://www.wjgnet.com/1007-9327/full/v26/i6/598.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v26.i6.598 |
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