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Articles Published Processes
3/26/2020 3:33:10 AM | Browse: 607 | Download: 939
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Received |
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2019-11-04 08:56 |
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Peer-Review Started |
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2019-11-04 08:56 |
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To Make the First Decision |
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Return for Revision |
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2019-12-06 05:51 |
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Revised |
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2019-12-12 03:19 |
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Second Decision |
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2020-02-14 05:18 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-02-18 05:44 |
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Articles in Press |
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2020-02-18 05:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-03-20 07:32 |
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Publish the Manuscript Online |
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2020-03-26 03:33 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Review |
| Article Title |
Gut commensal bacteria, Paneth cells and their relations to radiation enteropathy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yan-Li Gao, Li-Hong Shao, Li-Hua Dong and Peng-Yu Chang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81874254 |
| National Natural Science Foundation of China |
81773353 |
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| Corresponding Author |
Peng-Yu Chang, MD, PhD, Doctor, Doctor, Department of Radiation Oncology and Therapy, The First Hospital of Jilin University, Xinmin Street, No. 71, Changchun 130021, Jilin Province, China. edvence@163.com |
| Key Words |
Gut commensal bacteria; Paneth cell; Radiation enteropathy; Epithelial homeostasis; Gut immunity; Intestinal defense |
| Core Tip |
In healthy individuals, Paneth cells restrict the overgrowth of commensal bacteria in the gut while killing luminal pathogenic bacteria by secreting antimicrobial peptides. Such a property protects crypt intestinal stem cells against bacterial infection, thus ensuring epithelial homeostasis in the steady state. Among the active pool of intestinal stem cells, apoptosis commonly occurs as a result of ionizing irradiation. Nevertheless, the intestinal epithelium will recover its integrity after sublethal irradiation. On this basis, the mechanism by which Paneth cells provide growth signals for intestinal stem cells to facilitate epithelial regeneration is easy to understand, whereas the automatic recovery of irradiated intestine from sublethal irradiation is perplexing. Being challenged with luminal bacteria, the degranulation of Paneth cells can be stimulated in a cholinergic- or inflammatory-substance-dependent manner. Then, Paneth cells can perform an antibacterial function that influences the inflammatory milieu in irradiated intestine. Therefore, radiation-induced intestinal bacterial dysbiosis can be managed. |
| Publish Date |
2020-03-26 03:33 |
| Citation |
Gao YL, Shao LH, Dong LH, Chang PY. Gut commensal bacteria, Paneth cells and their relations to radiation enteropathy. World J Stem Cells 2020; 12(3): 188-202 |
| URL |
https://www.wjgnet.com/1948-0210/full/v12/i3/188.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v12.i3.188 |
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