Publication Name	World Journal of Gastroenterology
Manuscript ID	5223
Country	Argentina

Received	2013-08-23 08:46
Peer-Review Started	2013-08-24 09:39
To Make the First Decision	2013-09-09 16:55
Return for Revision	2013-09-15 19:38
Revised	2013-09-17 02:38
Second Decision	2013-10-21 17:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-10-22 07:45
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-01-10 15:02
Publish the Manuscript Online	2014-01-19 14:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Topic Highlights
Article Title	Core promoter: A critical region where the hepatitis B virus makes decisions
Manuscript Source	Invited Manuscript
All Author List	Jorge Quarleri
Funding Agency and Grant Number
Corresponding Author	Jorge Quarleri, PhD, Instituto de Investigaciones Biomédicas en Retrovirus y Sida, Universidad de Buenos Aires, CONICET, Buenos Aires C1121ABG, Argentina. quarleri@fmed.uba.ar
Key Words	Hepatitis B virus; Core promoter; Variants; Basal core promoter; Transcription regulation
Core Tip	This review summarized the progress in our understanding of the core promoter of hepatitis B virus. This critical genomic region is involved in regulating hepatitis B virus (HBV) gene expression and viral replication, involving both host and virus-derived factors on its regulation. Such pivotal functions appear modified when genomic variations are detected and clinical implications are characterized. This review emphasizes several aspects of the HBV core promoter molecular biology and highlights its role on HBV life cycle. Finally, the most frequent genomic variations with their consequent clinical correlations are described.
Publish Date	2014-01-19 14:17
Citation	Quarleri J. Core promoter: A critical region where the hepatitis B virus makes decisions. World J Gastroenterol 2014; 20(2): 425-435
URL	http://www.wjgnet.com/1007-9327/full/v20/i2/425.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i2.425

Full Article (PDF)	WJG-20-425.pdf
Full Article (Word)	WJG-20-425.doc
Manuscript File	5223-Review.docx
Answering Reviewers	5223-Answering reviewers.pdf
Copyright License Agreement	5223-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	Language 5223.docx
Peer-review Report	5223-Peer review(s).pdf
Scientific Editor Work List	5223-Scientific editor work list.doc