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Articles Published Processes
4/6/2020 8:11:47 AM | Browse: 751 | Download: 1225
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Received |
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2019-10-23 21:23 |
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Peer-Review Started |
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2019-10-23 21:23 |
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To Make the First Decision |
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Return for Revision |
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2019-12-12 04:44 |
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Revised |
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2020-01-18 18:30 |
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Second Decision |
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2020-02-09 06:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2020-02-11 18:32 |
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Articles in Press |
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2020-02-11 18:32 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2020-04-01 01:46 |
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Publish the Manuscript Online |
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2020-04-06 08:11 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Lack of Syndecan-1 produces significant alterations in whole-body composition, metabolism and glucose homeostasis in mice
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Anil Kumar Jaiswal, Mohanraj Sadasivam, Susan Aja and Abdel Rahim A Hamad |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Abdel Rahim A Hamad, PhD, Associate Professor, Department of Pathology, School of Medicine, Johns Hopkins University, Ross 66G, 720 Rutland Ave, Baltimore, MD 21205, United States. ahamad@jhmi.edu |
| Key Words |
Syndecan-1; High fat diet; Indirect calorimetry; Energy expenditure; IL-17; Feeding pattern |
| Core Tip |
Obesity is a disease state with serious adverse metabolic complications that currently has no cure. Identifying key modulators is required for developing effective cures. Here we investigated Syndecan-1 (Sdc1), a member of the heparan sulfate proteoglycan family for its roles in regulating obesity and glucose homeostasis. Sdc1 knockout (Sdc1 KO) mice have reduced body weight with decreases in fat and lean masses under both chow and high fat diet conditions. The reduced body weight was not due to changes in food intakes, but Sdc1 KO mice exhibited altered feeding behavior as they ate more during the dark phase and less during the light phase than wild type mice. In addition, Sdc1 KO mice suffered from high rate of energy expenditure, glucose intolerance and insulin resistance. Our results reveal critical multisystem and opposing roles for Sdc1 in regulating normal energy balance and glucose homeostasis. |
| Publish Date |
2020-04-06 08:11 |
| Citation |
Jaiswal AK, Sadasivam M, Aja S, Hamad ARA. Lack of Syndecan-1 produces significant alterations in whole-body composition, metabolism and glucose homeostasis in mice. World J Diabetes 2020; 11(4): 126-136 |
| URL |
https://www.wjgnet.com/1948-9358/full/v11/i4/126.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v11.i4.126 |
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