Publication Name	World Journal of Gastroenterology
Manuscript ID	5228
Country	Taiwan

Received	2013-08-24 08:19
Peer-Review Started	2013-08-24 10:07
To Make the First Decision
Return for Revision
Revised	2013-11-01 15:25
Second Decision	2013-11-13 10:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-11-13 14:42
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-12-12 19:29
Publish the Manuscript Online	2014-01-20 16:41

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Topic Highlights
Article Title	Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Chia-Chi Hsu, Hsin-Chen Lee and Yau-Huei Wei
Funding Agency and Grant Number	Funding Agency Grant Number Grant for the Center of Excellence for Cancer Research at Taipei Veterans General Hospital from the Ministry of Health and Welfare of the Executive Yuan DOH102-TDC-111-007 the Aim for the Top University Plan of the Ministry of Education and National Science Council of Taiwan NSC101-2320-B-010-068-MY3 the Aim for the Top University Plan of the Ministry of Education and National Science Council of Taiwan NSC100-2320-B-010-024-MY3
Corresponding Author	Hsin-Chen Lee, PhD, Institute of Pharmacology, School of Medicine, National Yang-Ming University, No. 155, Li-Nong St., Sec. 2, Taipei 112, Taiwan. hclee2@ym.edu.tw
Key Words	Hepatocellular carcinoma; Somatic mitochondrial DNA mutations; Mitochondrial dysfunction
Core Tip	In this review, we summarize the recent findings on the somatic mtDNA alterations identified in hepatocellular carcinoma (HCC) and their relationships with the clinicopathological features of HCC. We suggest that somatic mtDNA mutations and a decrease in the mtDNA copy number are common events in HCC and that a mitochondrial dysfunction-activated signaling cascade may play an important role in the progression of HCC. Elucidation of the retrograde signaling pathways in HCC and the quest for strategies to block some of these pathways will be instrumental for the development of novel treatments for this and other malignancies.
Publish Date	2014-01-20 16:41
Citation	Hsu CC, Lee HC, Wei YH. Mitochondrial DNA alterations and mitochondrial dysfunction in the progression of hepatocellular carcinoma. World J Gastroenterol 2013; 19(47): 8880-8886
URL	http://www.wjgnet.com/1007-9327/full/v19/i47/8880.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i47.8880

Full Article (PDF)	WJG-19-8880.pdf
Manuscript File	5228-Review.docx
Answering Reviewers	5228-Answering reviewers.pdf
Copyright License Agreement	5228-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	5228-Language certificate.pdf
Peer-review Report	5228-Peer review(s).pdf
Scientific Editor Work List	5228-Scientific editor work list.doc