Publication Name	World Journal of Gastroenterology
Manuscript ID	52320
Country	Australia

Received	2019-10-28 05:01
Peer-Review Started	2019-10-28 05:03
To Make the First Decision
Return for Revision	2019-12-12 13:16
Revised	2020-01-06 22:20
Second Decision	2020-03-08 09:11
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2020-03-09 07:17
Articles in Press	2020-03-09 07:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2020-03-10 08:36
Publish the Manuscript Online	2020-03-14 15:03

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Medicine, General & Internal
Manuscript Type	Minireviews
Article Title	Abnormal liver function tests associated with severe rhabdomyolysis
Manuscript Source	Invited Manuscript
All Author List	Andy KH Lim
ORCID	Author(s) ORCID Number Andy KH Lim http://orcid.org/0000-0001-7816-4724
Funding Agency and Grant Number
Corresponding Author	Andy KH Lim, FRACP, MBBS, MD, PhD, Senior Lecturer, Staff Physician, Department of General Medicine, Monash Health, and Department of Medicine, School of Clinical Sciences, Monash University, 246 Clayton Road, Clayton VIC 3168, Australia. andy.lim@monash.edu
Key Words	Rhabdomyolysis; Muscle; Creatine kinase; Liver function tests; Alanine aminotransferase; Aspartate aminotransferase
Core Tip	There is observational and experimental data demonstrating that serum alanine and aspartate aminotransferases can be elevated in patients with rhabdomyolysis due to muscle release of these enzymes, and cause confusion with liver disease. Clinicians should firstly appreciate this association exists and secondly, understand the typical pattern and trajectory of the levels of creatine kinase and aminotransferases in the setting of rhabdomyolysis. An atypical trajectory, concurrently elevated bilirubin or γ-glutamyl transferase, or serum alanine aminotransferase levels above 800 U/L are inconsistent with isolated muscle injury as the cause of the elevated aminotransferases, and further investigation for liver disease may be warranted.
Publish Date	2020-03-14 15:03
Citation	Lim AKH. Abnormal liver function tests associated with severe rhabdomyolysis. World J Gastroenterol 2020; 26(10): 1020-1028
URL	https://www.wjgnet.com/1007-9327/full/v26/i10/1020.htm
DOI	https://dx.doi.org/10.3748/wjg.v26.i10.1020

Full Article (PDF)	WJG-26-1020.pdf
Full Article (Word)	WJG-26-1020.docx
Manuscript File	52320-Review.docx
Answering Reviewers	52320-Answering reviewers.pdf
Audio Core Tip	52320-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	52320-Conflict-of-interest statement.pdf
Copyright License Agreement	52320-Copyright license agreement.pdf
Peer-review Report	52320-Peer-review(s).pdf
Scientific Misconduct Check	52320-Scientific misconduct check.pdf
Scientific Editor Work List	52320-Scientific editor work list.pdf
CrossCheck Report	52320-CrossCheck report.pdf